Research Article
Diagnostic Accuracy of Serum Cystatin C for Early Recognition of Nephropathy in Type 2 Diabetes Mellitus
Table 2
Variables according to different grades of diabetic nephropathy.
| | Variables | Total cases (n = 50) | Normoalbuminuria (n = 26) | Microalbuminuria (n = 20) | Macroalbuminuria (n = 4) | value |
| | Age (years) | 51.6 ± 11.0 | 51 ± 10 | 51 ± 10 | 58 ± 22 | 0.536 | | Bodyweight (kg) | 66.4 ± 12.6 | 66 ± 12.6 | 68.1 ± 12.8 | 60.3 ± 14.3 | 0.528 | | BMI (kg/m2) | 26.2 ± 5.6 | 26.2 ± 6.2 | 26.6 ± 5.3 | 23.9 ± 2.7 | 0.686 | | W : H ratio | 1.03 ± 0.09 | 1.04 ± 0.07 | 1.03 ± 0.11 | 1.00 ± 0.07 | 0.774 | | Pulse | 78 ± 7 | 79 ± 6 | 77 ± 9 | 76 ± 10 | 0.581 | | SBP (mm of Hg) | 125 ± 16 | 122 ± 13 | 126 ± 16 | 135 ± 31 | 0.311 | | DBP (mm of Hg) | 77 ± 9 | 76 ± 9 | 79 ± 9 | 75 ± 13 | 0.556 | | Duration of DM (years) | 5 (2, 10) | 4 (1, 8) | 6 (3, 13) | 5 (1, 15) | 0.275 | | Fasting blood glucose (mg/dl) | 158.5 (137.0, 214.5) | 157.5 (136.5, 214.0) | 158.5 (143.7, 216.0) | 169 (121.3, 486.8) | 0.994 | | Postprandial (mg/dl) | 281.5 (214.8, 382.3) | 272.0 (214.5, 371.8) | 295.5 (223.7, 371.3) | 320.5 (175.8, 802.8) | 0.886 | | HbA1c (%) | 7.5 ± 2.0 | 7.3 ± 1.8 | 8.1 ± 2.4 | 7.1 ± 1.2 | 0.384 | | Triglycerides (mg/dl) | 204.6 ± 96.9 | 184.8 ± 87.4 | 229.9 ± 107.6 | 206.9 ± 94.0 | 0.301 | | Total cholesterol (mg/dl) | 197.1 ± 50.1 | 193.2 ± 52.7 | 206.0 ± 50.0 | 173.5 ± 27.4 | 0.454 | | HDL cholesterol (mg/dl) | 40.4 ± 5.9 | 38.8 ± 6.2 | 41.1 ± 4.0 | 47.3 ± 7.7 | 0.018 | | Serum creatinine (mg/dl) | 0.85 ± 0.23 | 0.87 ± 0.21 | 0.82 ± 0.22 | 0.88 ± 0.3 | 0.773 | | Serum cystatin C (mg/L) | 1.07 ± 0.38 | 0.94 ± 0.22 | 1.07 ± 0.41 | 1.63 ± 0.66 | <0.001 | | UACR | 27.6 (10.6, 125.55) | 11.9 (7.4, 21.0) | 92.5 (56.3, 164.4) | 618.4 (402.0, 705.2) | <0.001 | | eGFRCG (creat) | 94.9 ± 36.2 | 90.9 ± 24.1 | 100.6 ± 39.5 | 92.1 ± 79.1 | 0.738 | | eGFRMDRD (creat) | 96.5 ± 35.6 | 94.0 ± 30.1 | 99.3 ± 40.1 | 98.6 ± 55.0 | 0.706 | | eGFRCKD-EPI (creat) | 109.3 ± 20.6 | 107.1 ± 17.4 | 112.7 ± 21.7 | 106.3 ± 36 | 0.634 | | eGFRCKD-EPI (Cyst C) | 80.5 ± 26.3 | 94.1 ± 16.7 | 74.3 ± 27.5 | 45.7 ± 22.5 | 0.162 |
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One-way ANOVA (for normally distributed variables) and the Kruskal–Wallis test (nonnormally distributed) were performed followed by post hoc analysis.
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