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International Journal of Optics
Volume 2012, Article ID 276367, 10 pages
Research Article

Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System

1Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, University of Texas at Arlington, Arlington, TX 76019, USA
2State key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 10875, China

Received 15 July 2011; Revised 21 October 2011; Accepted 24 October 2011

Academic Editor: Javier A. Jo

Copyright © 2012 Zi-Jing Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the feasibility of three-dimensional (3D) volumetric diffuse optical tomography for small animal imaging by using a CCD-camera-based imaging system with a newly developed depth compensation algorithm (DCA). Our computer simulations and laboratory phantom studies have demonstrated that the combination of a CCD camera and DCA can significantly improve the accuracy in depth localization and lead to reconstruction of 3D volumetric images. This approach may present great interests for noninvasive 3D localization of an anomaly hidden in tissue, such as a tumor or a stroke lesion, for preclinical small animal models.