Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells

Figure 2

Advantages of using multicomponent photosensitizing molecules and their different roles in TPDT: (1) Conjugating a PS to NPs and antibodies increases its stability in the circulation and tumour selectivity. (2) Antibodies recognise specific antigens on the surface of cells enabling specific binding. (3) Nanoparticles enhance endothelial membrane by increasing solubility. (4) Because of increased solubility, there is maximum absorption resulting in efficient accumulation of photosensitizer inside the cancer cell. (5) Ultimately, there is increased cytotoxic effect in PDT.