Aberrant Methylation Inactivates Transforming Growth Factor 𝛽 Receptor I in Head and Neck Squamous Cell Carcinoma

Figure 3

Schematic depiction of 𝑇𝛽𝑅-𝐼 expression by semiquantitative RT-PCR, and hypermethylation by MSP. Tumors with methylated (red bars) and nonmethylated (blue bars) genes are depicted in association with 𝑇𝛽𝑅-𝐼 levels of expression. Columns (white, grey, and dark grey) correspond to relative expression levels (arbitrary units) of 𝑇𝛽𝑅-𝐼 determined by semiquantitative RT-PCR. Methylated genes are associated with lower expression levels of the 𝑇𝛽𝑅-𝐼 gene.