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International Journal of Otolaryngology
Volume 2010 (2010), Article ID 137128, 4 pages
http://dx.doi.org/10.1155/2010/137128
Clinical Study

Long-Term Histologic Changes in Nasal Mucosa after Total Laryngectomy

1Department of Otorhinolaryngology/Head and Neck Surgery, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey
2Department of Otorhinolaryngology/Head and Neck Surgery, Namık Kemal University, Tekirdağ , Turkey
3Department of Otorhinolaryngology/Head and Neck Surgery, Gaziosmanpasa University, Tokat 60100, Turkey
4Department of Pathology, Taksim Education and Research Hospital, Istanbul, Turkey
5Department of Otorhinolaryngology/Head and Neck Surgery, Taksim Education and Research Hospital, Istanbul, Turkey

Received 1 October 2009; Revised 12 January 2010; Accepted 5 February 2010

Academic Editor: Richard L. Doty

Copyright © 2010 Çiğdem Tepe Karaca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine the long-term histopathologic changes in nasal mucosa and the relationship between progression of the histopathologic changes and the duration without air current stimulation. Material and Method. Biopsies were taken from the inferior turbinates of 11 laryngeal cancer patients after total laryngectomy. Specimens were stained with hematoksilen-eosin and several histopathologic parameters were examined under light microscopy. Results. All of the patients demonstrated at least one histopathologic abnormality (100%, ). Goblet destruction and stromal fibrosis were the most common findings (81%, ), followed by focal epithelial atrophy and subepithelial seromusinous gland destruction (45%, ), neovascularization and congestion (36%, ), complete epithelial atrophy and mixoid degeneration (27%, ). According to the duration between laryngectomy and biopsy, patients were grouped in to three: group 1; less than 12 months (36%, ), group 2; 12–36 months (18%, ), and group 3; more than 36 months (45%, ). Only congestion was found to be decreased as the duration increased ( ). Conclusion. In laryngeal cancer patients histopathologic changes occur in nasal mucosa eventuate due to the cessation of air current stimulation, however there was no relation between progression of the histopathologic findings and the duration of cessation.