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International Journal of Otolaryngology
Volume 2010 (2010), Article ID 154948, 5 pages
http://dx.doi.org/10.1155/2010/154948
Case Report

Sinonasal Schwannoma with New Bone Formation Expressing Bone Morphogenic Protein

Department of Otolaryngology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hazama-machi, Yufu, Oita 879-5593, Japan

Received 16 September 2010; Accepted 22 November 2010

Academic Editor: Fuad Baroody

Copyright © 2010 Satoru Kodama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Schwannoma is a benign tumor that arises from the sheath of myelinated nerve fibers and may occur in any part of the body. Osteogenesis in schwannoma is extremely rare and, to date, new bone formation in sinonasal schwannoma has not yet been reported. Here, we describe the first reported case of sinonasal schwannoma with new bone formation. The tumor was successfully treated by endoscopic sinus surgery, and the patient showed no evidence of recurrence 24 months postoperatively. Immunohistochemically, the tumor expressed bone morphogenic protein 4, indicating a possible role of this protein in the new bone formation in schwannomas.