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International Journal of Otolaryngology
Volume 2010 (2010), Article ID 698014, 4 pages
Case Report

Late Simultaneous Metastasis of Renal Cell Carcinoma to the Submandibular and Thyroid Glands Seven Years after Radical Nephrectomy

1Department of Otolaryngology-Head & Neck Surgery, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK
2Department of Pathology, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK

Received 17 April 2010; Accepted 21 June 2010

Academic Editor: David W. Eisele

Copyright © 2010 Mohammed S. Miah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.