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International Journal of Otolaryngology
Volume 2011, Article ID 187623, 9 pages
http://dx.doi.org/10.1155/2011/187623
Review Article

Novel Therapeutic Strategies for Malignant Salivary Gland Tumors: Lessons Learned from Breast Cancer

1Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
2California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA

Received 13 April 2011; Revised 26 August 2011; Accepted 27 August 2011

Academic Editor: David W. Eisele

Copyright © 2011 Ryuichi Murase et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. A. Kester, B. J. M. Van Der Leede, P. T. Van Der Saag, and B. Van Der Burg, “Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation,” Journal of Biological Chemistry, vol. 272, no. 26, pp. 16637–16643, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. C. L. Clarke and R. L. Sutherland, “Progestin regulation of cellular proliferation,” Endocrine Reviews, vol. 11, no. 2, pp. 266–301, 1990. View at Google Scholar · View at Scopus
  3. C. X. Ma, C. G. Sanchez, and M. J. Ellis, “Predicting endocrine therapy responsiveness in breast cancer,” Oncology, vol. 23, no. 2, pp. 133–142, 2009. View at Google Scholar · View at Scopus
  4. M. H. Jeng, C. J. Parker, and V. C. Jordan, “Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation,” Cancer Research, vol. 52, no. 23, pp. 6539–6546, 1992. View at Google Scholar · View at Scopus
  5. B. van der Burg, E. Kalkhoven, L. Isbrucker, and S. W. De Laat, “Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions,” Journal of Steroid Biochemistry and Molecular Biology, vol. 42, no. 5, pp. 457–465, 1992. View at Publisher · View at Google Scholar · View at Scopus
  6. R. L. Sutherland, R. E. Hall, G. Y. N. Pang, E. A. Musgrove, and C. L. Clarke, “Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells,” Cancer Research, vol. 48, no. 18, pp. 5084–5091, 1988. View at Google Scholar · View at Scopus
  7. T. Sumida, Y. Itahana, H. Hamakawa, and P. Y. Desprez, “Reduction of human metastatic breast cancer cell aggressiveness on introduction of either form A or B of the progesterone receptor and then treatment with progestins,” Cancer Research, vol. 64, no. 21, pp. 7886–7892, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. M. D. Williams, D. Roberts, G. R. Blumenschein et al., “Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients,” American Journal of Surgical Pathology, vol. 31, no. 11, pp. 1645–1652, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. K. B. Horwitz, “Mechanisms of hormone resistance in breast cancer,” Breast Cancer Research and Treatment, vol. 26, no. 2, pp. 119–130, 1993. View at Google Scholar · View at Scopus
  10. R. Ismail-Khan and M. M. Bui, “A review of triple-negative breast cancer,” Cancer Control, vol. 17, no. 3, pp. 173–176, 2010. View at Google Scholar · View at Scopus
  11. H. Miyake, I. Hara, and H. Eto, “Clinical outcome of maximum androgen blockade using flutamide as second-line hormonal therapy for hormone-refractory prostate cancer,” BJU International, vol. 96, no. 6, pp. 791–795, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. L. Klotz and P. Schellhammer, “Combined androgen blockade: the case for bicalutamide,” Clinical Prostate Cancer, vol. 3, no. 4, pp. 215–219, 2005. View at Google Scholar · View at Scopus
  13. X. Yuan and S. P. Balk, “Mechanisms mediating androgen receptor reactivation after castration,” Urologic Oncology, vol. 27, no. 1, pp. 36–41, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. H. I. Scher and C. L. Sawyers, “Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis,” Journal of Clinical Oncology, vol. 23, no. 32, pp. 8253–8261, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. M. E. Grossmann, H. Huang, and D. J. Tindall, “Androgen receptor signaling in androgen-refractory prostate cancer,” Journal of the National Cancer Institute, vol. 93, no. 22, pp. 1687–1697, 2001. View at Google Scholar · View at Scopus
  16. J. D. Debes and D. J. Tindall, “Mechanisms of androgen-refractory prostate cancer,” New England Journal of Medicine, vol. 351, no. 15, pp. 1488–1490, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. C. D. Chen, D. S. Welsbie, C. Tran et al., “Molecular determinants of resistance to antiandrogen therapy,” Nature Medicine, vol. 10, no. 1, pp. 33–39, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. T. Hara, K. Nakamura, H. Araki, M. Kusaka, and M. Yamaoka, “Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline,” Cancer Research, vol. 63, no. 17, pp. 5622–5628, 2003. View at Google Scholar · View at Scopus
  19. M. E. Taplin and S. P. Balk, “Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence,” Journal of Cellular Biochemistry, vol. 91, no. 3, pp. 483–490, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. T. Hara, H. Miyazaki, A. Lee, C. P. Tran, and R. E. Reiter, “Androgen receptor and invasion in prostate cancer,” Cancer Research, vol. 68, no. 4, pp. 1128–1135, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. L. Bonaccorsi, V. Carloni, M. Muratori et al., “Androgen receptor expression in prostate carcinoma cells suppresses α6β4 integrin-mediated invasive phenotype,” Endocrinology, vol. 141, no. 9, pp. 3172–3182, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Cinar, K. S. Koeneman, M. Edlund, G. S. Prins, H. E. Zhau, and L. W. K. Chung, “Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line,” Cancer Research, vol. 61, no. 19, pp. 7310–7317, 2001. View at Google Scholar · View at Scopus
  23. R. T. Burkman, “Reproductive hormones and cancer: ovarian and colon cancer,” Obstetrics and Gynecology Clinics of North America, vol. 29, no. 3, pp. 527–540, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. C. M. Greiser, E. M. Greiser, and M. Dören, “Menopausal hormone therapy and risk of lung cancer-Systematic review and meta-analysis,” Maturitas, vol. 65, no. 3, pp. 198–204, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. C. L. Pearce, K. Chung, M. C. Pike, and A. H. Wu, “Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestin,” Cancer, vol. 115, no. 3, pp. 531–539, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. H. Zhou, M. P. Luo, A. H. Schönthal et al., “Effect of reproductive hormones on ovarian epithelial tumors: I. effect on cell cycle activity,” Cancer Biology & Therapy, vol. 1, no. 3, pp. 300–306, 2002. View at Google Scholar · View at Scopus
  27. R. Kennelly, D. O. Kavanagh, A. M. Hogan, and D. C. Winter, “Oestrogen and the colon: potential mechanisms for cancer prevention,” The Lancet Oncology, vol. 9, no. 4, pp. 385–391, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. H. B. Hellquist, M. G. Karlsson, and C. Nilsson, “Salivary duct carcinoma - A highly aggressive salivary gland tumour with overexpression of c-erbB-2,” Journal of Pathology, vol. 172, no. 1, pp. 35–44, 1994. View at Google Scholar · View at Scopus
  29. M. Pia-Foschini, J. S. Reis-Filho, and V. Eusebi, “Salivary gland-like tumours of the breast: surgical and molecular pathology,” Journal of Clinical Pathology, vol. 56, no. 7, pp. 497–506, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. S. I. Camelo-Piragua, C. Habib, P. Kanumuri, C. E. Lago, H. S. Mason, and C. N. Otis, “Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature,” Human Pathology, vol. 40, no. 6, pp. 887–892, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. C. Marchiò, B. Weigelt, and J. S. Reis-Filho, “Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas),” Journal of Clinical Pathology, vol. 63, no. 3, pp. 220–228, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. A. Milano, F. Longo, M. Basile, R. V. Iaffaioli, and F. Caponigro, “Recent advances in the treatment of salivary gland cancers: emphasis on molecular targeted therapy,” Oral Oncology, vol. 43, no. 8, pp. 729–734, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. S. A. Laurie and L. Licitra, “Systemic therapy in the palliative management of advanced salivary gland cancers,” Journal of Clinical Oncology, vol. 24, no. 17, pp. 2673–2678, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. J. G. Batsakis, J. A. Regezi, M. A. Luna, and A. El-Naggar, “Histogenesis of salivary gland neoplasms: a postulate with prognostic implications,” Journal of Laryngology and Otology, vol. 103, no. 10, pp. 939–944, 1989. View at Google Scholar · View at Scopus
  35. I. Dardick and A. W. van Nostrand, “Morphogenesis of salivary gland tumors. A prerequisite to improving classification,” Pathology Annual, vol. 22, pp. 1–53, 1987. View at Google Scholar · View at Scopus
  36. B. Glisson, A. D. Colevas, R. Haddad et al., “HER2 expression in salivary gland carcinomas: dependence on histological subtype,” Clinical Cancer Research, vol. 10, no. 3, pp. 944–946, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. F. R. Pires, O. P. De Almeida, V. C. De Araújo, and L. P. Kowalski, “Prognostic Factors in Head and Neck Mucoepidermoid Carcinoma,” Archives of Otolaryngology—Head and Neck Surgery, vol. 130, no. 2, pp. 174–180, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. E. R. Fisher, R. M. Gregorio, A. S. Palekar, and J. D. Paulson, “Mucoepidermoid and squamous cell carcinomas of breast with reference to squamous metaplasia and giant cell tumors,” American Journal of Surgical Pathology, vol. 7, no. 1, pp. 15–27, 1983. View at Google Scholar · View at Scopus
  39. A. S. Patchefsky, C. M. Frauenhoffer, R. A. Krall, and H. S. Cooper, “Low-grade mucoepidermoid carcinoma of the breast,” Archives of Pathology and Laboratory Medicine, vol. 103, no. 4, pp. 196–198, 1979. View at Google Scholar · View at Scopus
  40. J. Kovi, H. D. Duong, and L. D. Leffall, “High-grade mucoepidermoid carcinoma of the breast,” Archives of Pathology and Laboratory Medicine, vol. 105, no. 11, pp. 612–614, 1981. View at Google Scholar · View at Scopus
  41. H. Hornychová, A. Ryška, J. Betlach et al., “Mucoepidermoid carcinoma of the breast,” Neoplasma, vol. 54, no. 2, pp. 168–172, 2007. View at Google Scholar · View at Scopus
  42. V. Gómez-Aracil, E. M. Artal, J. Azua-Romeo, R. M. Alvira, J. Azúa-Blanco, and A. Arraiza Goicoechea, “Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the breast: a case report,” Acta Cytologica, vol. 50, no. 3, pp. 344–348, 2006. View at Google Scholar · View at Scopus
  43. M. G. Berry, C. Caldwell, and R. Carpenter, “Mucoepidermoid carcinoma of the breast: a case report and review of the literature,” European Journal of Surgical Oncology, vol. 24, no. 1, pp. 78–80, 1998. View at Publisher · View at Google Scholar · View at Scopus
  44. A. S. Y. Leong and J. A. R. Williams, “Mucoepidermoid carcinoma of the breast: high grade variant,” Pathology, vol. 17, no. 3, pp. 516–521, 1985. View at Google Scholar · View at Scopus
  45. N. Hastrup and M. Sehested, “High-grade mucoepidermoid carcinoma of the breast,” Histopathology, vol. 9, no. 8, pp. 887–892, 1985. View at Google Scholar · View at Scopus
  46. H. Luchtrath and R. Moll, “Mucoepidermoid mammary carcinoma. Immunohistochemical and biochemical analyses of intermediate filaments,” Virchows Archiv—A Pathological Anatomy and Histopathology, vol. 416, no. 2, pp. 105–113, 1989. View at Google Scholar · View at Scopus
  47. G. Pettinato, L. Insabato, A. De Chiara, A. Manco, and G. Petrella, “High-grade mucoepidermoid carcinoma of the breast. Fine needle aspiration cytology and clinicopathologic study of a case,” Acta Cytologica, vol. 33, no. 2, pp. 195–200, 1989. View at Google Scholar · View at Scopus
  48. C. Markopoulos, H. Gogas, A. Livaditou, and D. Floros, “Mucoepidermoid carcinoma of the breast,” European Journal of Gynaecological Oncology, vol. 19, no. 3, pp. 291–293, 1998. View at Google Scholar · View at Scopus
  49. L. C. Chang, N. Lee, C. T. Lee, and J. S. Huang, “High-grade mucoepidermoid carcinoma of the breast: case report,” Changgeng Yi Xue Za Zhi, vol. 21, no. 3, pp. 352–357, 1998. View at Google Scholar · View at Scopus
  50. L. Di Tommaso, M. P. Foschini, T. Ragazzini et al., “Mucoepidermoid carcinoma of the breast,” Virchows Archiv, vol. 444, no. 1, pp. 13–19, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. W. A. A. Tjalma, I. O. J. Verslegers, P. A. J. De Loecker, and E. A. E. Van Marck, “Low and high grade mucoepidermoid carcinomas of the breast,” European Journal of Gynaecological Oncology, vol. 23, no. 5, pp. 423–425, 2002. View at Google Scholar · View at Scopus
  52. S. Ratanarapee, N. Prinyar-Nussorn, N. Chantarakul, and P. Pacharee, “High-grade mucoepidermoid carcinoma of the breast. A case report,” Journal of the Medical Association of Thailand, vol. 66, no. 10, pp. 642–648, 1983. View at Google Scholar · View at Scopus
  53. W. Hanna and H. J. Kahn, “Ultrastructural and immunohistochemical characteristics of mucoepidermoid carcinoma of the breast,” Human Pathology, vol. 16, no. 9, pp. 941–946, 1985. View at Google Scholar · View at Scopus
  54. G. Tonon, S. Modi, L. Wu et al., “t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway,” Nature Genetics, vol. 33, no. 2, pp. 208–213, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. G. Tonon, K. S. Gehlhaus, R. Yonescu, F. J. Kaye, and I. R. Kirsch, “Multiple reciprocal translocations in salivary gland mucoepidermoid carcinomas,” Cancer Genetics and Cytogenetics, vol. 152, no. 1, pp. 15–22, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  56. A. Behboudi, F. Enlund, M. Winnes et al., “Molecular classification of mucoepidermoid carcinomas -Prognostic significance of the MECT1-MAML2 fusion oncogene,” Genes Chromosomes and Cancer, vol. 45, no. 5, pp. 470–481, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  57. A. Nordkvist, H. Gustafsson, M. Juberg-Ode, and G. Stenman, “Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma,” Cancer Genetics and Cytogenetics, vol. 74, no. 2, pp. 77–83, 1994. View at Publisher · View at Google Scholar · View at Scopus
  58. S. J. Hotte, E. W. Winquist, E. Lamont et al., “Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a rincess Margaret Hospital Phase II Consortium study,” Journal of Clinical Oncology, vol. 23, no. 3, pp. 585–590, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. L. da Silva, L. Buck, P. T. Simpson et al., “Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis,” Virchows Archiv, vol. 454, no. 1, pp. 107–114, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. R. L. Dodd and N. J. Slevin, “Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies,” Oral Oncology, vol. 42, no. 8, pp. 759–769, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  61. J. Y. Ro, E. G. Silva, and H. S. Gallager, “Adenoid cystic carcinoma of the breast,” Human Pathology, vol. 18, no. 12, pp. 1276–1281, 1987. View at Google Scholar · View at Scopus
  62. M. Persson, Y. Andrén, J. Mark, H. M. Horlings, F. Persson, and G. Stenman, “Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 44, pp. 18740–18744, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  63. B. Weigelt, H. M. Horlings, B. Kreike et al., “Refinement of breast cancer classification by molecular characterization of histological special types,” Journal of Pathology, vol. 216, no. 2, pp. 141–150, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  64. L. Vila, H. Liu, S. Z. Al-Quran, D. P. Coco, H. J. Dong, and C. Liu, “Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland,” Modern Pathology, vol. 22, no. 10, pp. 1296–1302, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  65. M. G. Mastropasqua, E. Maiorano, G. Pruneri et al., “Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast,” Modern Pathology, vol. 18, no. 10, pp. 1277–1282, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  66. S. Azoulay, M. Laé, P. Fréneaux et al., “KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome,” Modern Pathology, vol. 18, no. 12, pp. 1623–1631, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  67. G. M. Crisi, S. A. Marconi, G. Makari-Judson, and R. A. Goulart, “Expression of c-kit in adenoid cystic carcinoma of the breast,” American Journal of Clinical Pathology, vol. 124, no. 5, pp. 733–739, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. P. C. Edwards, T. Bhuiya, and R. D. Kelsch, “C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 95, no. 5, pp. 586–593, 2003. View at Publisher · View at Google Scholar · View at PubMed
  69. V. A. Holst, C. E. Marshall, C. A. Moskaluk, and H. F. Frierson, “Kit protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma,” Modern Pathology, vol. 12, no. 10, pp. 956–960, 1999. View at Google Scholar · View at Scopus
  70. Y. M. Jeng, C. Y. Lin, and H. C. Hsu, “Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma,” Cancer Letters, vol. 154, no. 1, pp. 107–111, 2000. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Nordkvist, J. Mark, H. Gustafsson, G. Bang, and G. Stenman, “Non-random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands,” Genes Chromosomes and Cancer, vol. 10, no. 2, pp. 115–121, 1994. View at Publisher · View at Google Scholar · View at Scopus
  72. L. Barnes, U. Rao, J. Krause, L. Contis, A. Schwartz, and P. Scalamogna, “Salivary duct carcinoma. Part I. A clinicopathologic evaluation and DNA image analysis of 13 cases with review of the literature,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 78, no. 1, pp. 64–73, 1994. View at Google Scholar · View at Scopus
  73. O. Kleinsasser, H. J. Klein, and G. Hübner, “Salivary duct carcinoma. A group of salivary gland tumors analogous to mammary duct carcinoma,” Archiv fur Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde, vol. 192, no. 1, pp. 100–105, 1968. View at Google Scholar · View at Scopus
  74. M. F. Press, L. Bernstein, P. A. Thomas et al., “HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas,” Journal of Clinical Oncology, vol. 15, no. 8, pp. 2894–2904, 1997. View at Google Scholar · View at Scopus
  75. B. Moy and P. E. Goss, “Lapatinib: current status and future directions in breast cancer,” Oncologist, vol. 11, no. 10, pp. 1047–1057, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  76. H. C.J. Jaspers, B. M. Verbist, R. Schoffelen et al., “Androgen receptor-positive salivary duct carcinoma: a disease entity with promising new treatment options,” Journal of Clinical Oncology, vol. 29, no. 16, pp. e473–e476, 2011. View at Publisher · View at Google Scholar · View at PubMed
  77. M. F. Press, M. C. Pike, G. Hung et al., “Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis,” Cancer Research, vol. 54, no. 21, pp. 5675–5682, 1994. View at Google Scholar · View at Scopus
  78. L. D. Locati, F. Perrone, M. Losa et al., “Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs),” Oral Oncology, vol. 45, no. 11, pp. 986–990, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  79. M. D. Gibbons, U. Manne, W. R. Carroll, G. E. Peters, H. L. Weiss, and W. E. Grizzle, “Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands,” Laryngoscope, vol. 111, no. 8, pp. 1373–1378, 2001. View at Google Scholar · View at Scopus
  80. C. Giannoni, A. K. El-Naggar, N. G. Ordñoez et al., “c-erbB-2/neu oncogene and Ki-67 analysis in the assessment of palatal salivary gland neoplasms,” Otolaryngology—Head and Neck Surgery, vol. 112, no. 3, pp. 391–398, 1995. View at Publisher · View at Google Scholar · View at Scopus
  81. L. H. P. Nguyen, M. J. Black, M. Hier, P. Chauvin, and L. Rochon, “HER2/neu and Ki-67 as prognostic indicators in mucoepidermoid carcinoma of salivary glands,” Journal of Otolaryngology, vol. 32, no. 5, pp. 328–331, 2003. View at Google Scholar · View at Scopus
  82. M. Jaehne, K. Roeser, T. Jaekel, J. David Schepers, N. Albert, and T. Löning, “Clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases,” Cancer, vol. 103, no. 12, pp. 2526–2533, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  83. A. Etges, D. S. Pinto, L. P. Kowalski, F. A. Soares, and V. C. Araújo, “Salivary duct carcinoma: immunohistochemical profile of an aggressive salivary gland tumour,” Journal of Clinical Pathology, vol. 56, no. 12, pp. 914–918, 2003. View at Publisher · View at Google Scholar · View at Scopus
  84. A. Skálová, I. Stárek, V. Kuerová, P. Szépe, and L. Plank, “Salivary duct carcinoma—a highly aggressive salivary gland tumor with HER-2/neu oncoprotein overexpression,” Pathology Research and Practice, vol. 197, no. 9, pp. 621–626, 2001. View at Google Scholar
  85. C. Y. Fan, M. F. Melhem, A. Sefic Hosal, J. Rubin Grandis, and E. Leon Barnes, “Expression of androgen receptor, epidermal growth factor receptor, and transforming growth factor α in salivary duct carcinoma,” Archives of Otolaryngology—Head and Neck Surgery, vol. 127, no. 9, pp. 1075–1079, 2001. View at Google Scholar · View at Scopus
  86. C. Kari, T. O. Chan, M. Rocha de Quadros, and U. Rodeck, “Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage,” Cancer Research, vol. 63, no. 1, pp. 1–5, 2003. View at Google Scholar · View at Scopus
  87. M. A. Shupnik, “Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation,” Oncogene, vol. 23, no. 48, pp. 7979–7989, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  88. M. P. Hoang, D. L. Callender, J. J. Sola Gallego et al., “Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma,” International journal of oncology, vol. 19, no. 4, pp. 865–871, 2001. View at Google Scholar · View at Scopus
  89. M. D. Williams, D. B. Roberts, M. S. Kies, L. Mao, R. S. Weber, and A. K. El-Naggar, “Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance,” Clinical Cancer Research, vol. 16, no. 8, pp. 2266–2274, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  90. T. Shien, T. Tashiro, M. Omatsu et al., “Frequent overexpression of epidermal growth factor receptor (EGFR) in mammary high grade ductal carcinomas with myoepithelial differentiation,” Journal of Clinical Pathology, vol. 58, no. 12, pp. 1299–1304, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  91. M. R. Wick, D. M. Ockner, S. E. Mills, J. H. Ritter, and P. E. Swanson, “Homologous carcinomas of the breasts, skin, and salivary glands: a histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma,” American Journal of Clinical Pathology, vol. 109, no. 1, pp. 75–84, 1998. View at Google Scholar · View at Scopus
  92. G. White and G. G. Garcelon, “Estrogen and combined estrogen and x-ray therapy; their effects on advanced malignant salivary-gland tumors,” The New England Journal of Medicine, vol. 253, no. 10, pp. 410–412, 1955. View at Google Scholar
  93. J. P. Jeannon, J. V. Soames, H. Bell, and J. A. Wilson, “Immunohistochemical detection of oestrogen and progesterone receptors in salivary tumours,” Clinical Otolaryngology and Allied Sciences, vol. 24, no. 1, pp. 52–54, 1999. View at Publisher · View at Google Scholar · View at Scopus
  94. A. S. Miller, G. G. Hartman, S. Y. Chen, P. R. Edmonds, S. A. Brightman, and R. D. Harwick, “Estrogen receptor assay in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of salivary gland origin. An immunohistochemical study,” Oral Surgery Oral Medicine and Oral Pathology, vol. 77, no. 1, pp. 36–40, 1994. View at Google Scholar · View at Scopus
  95. P. J. Lamey, R. E. Leake, and S. K. Cowan, “Steroid hormone receptors in human salivary gland tumours,” Journal of Clinical Pathology, vol. 40, no. 5, pp. 532–534, 1987. View at Google Scholar · View at Scopus
  96. P. C. Shick, G. P. Riordan, and R. D. Foss, “Estrogen and progesterone receptors in salivary gland adenoid cystic carcinoma,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and, vol. 80, no. 4, pp. 440–444, 1995. View at Google Scholar
  97. L. Barnes, U. Rao, L. Contis, J. Krause, A. Schwartz, and P. Scalamogna, “Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 78, no. 1, pp. 74–80, 1994. View at Google Scholar · View at Scopus
  98. I. W. Dimery, L. A. Jones, R. P. Verjan, A. K. Raymond, H. Goepfert, and W. K. Hong, “Estrogen receptors in normal salivary gland and salivary gland carcinoma,” Archives of Otolaryngology—Head and Neck Surgery, vol. 113, no. 10, pp. 1082–1085, 1987. View at Google Scholar · View at Scopus
  99. J. E. Lewis, B. C. McKinney, L. H. Weiland, J. A. Ferreiro, and K. D. Olsen, “Salivary duct carcinoma: clinicopathologic and immunohistochemical review of 26 cases,” Cancer, vol. 77, no. 2, pp. 223–230, 1996. View at Publisher · View at Google Scholar · View at Scopus
  100. J. E. Barrera, K. R. Shroyer, S. Said et al., “Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer,” Head and neck pathology, vol. 2, no. 1, pp. 13–18, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  101. S. Dori, P. Trougouboff, R. David, and A. Buchner, “Immunohistochemical evaluation of estrogen and progesterone receptors in adenoid cystic carcinoma of salivary gland origin,” Oral Oncology, vol. 36, no. 5, pp. 450–453, 2000. View at Publisher · View at Google Scholar · View at Scopus
  102. F. R. Pires, D. E.D.C. Perez, O. P. De Almeida, and L. P. Kowalski, “Estrogen receptor expression in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma,” Pathology and Oncology Research, vol. 10, no. 3, pp. 166–168, 2004. View at Google Scholar
  103. S. M. Nasser, W. C. Faquin, and Y. Dayal, “Expression of androgen, estrogen, and progesterone receptors in salivary gland tumors: frequent expression of androgen receptor in a subset of malignant salivary gland tumors,” American Journal of Clinical Pathology, vol. 119, no. 6, pp. 801–806, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  104. S. B. Kapadia and L. Barnes, “Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma,” Modern Pathology, vol. 11, no. 11, pp. 1033–1038, 1998. View at Google Scholar · View at Scopus
  105. T. Moriki, S. Ueta, T. Takahashi, M. Mitani, and M. Ichien, “Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosis,” Cancer, vol. 93, no. 5, pp. 344–350, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  106. E. F. Foley, A. A. Jazaeri, M. A. Shupnik, O. Jazaeri, and L. W. Rice, “Selective loss of estrogen receptor β in malignant human colon,” Cancer Research, vol. 60, no. 2, pp. 245–248, 2000. View at Google Scholar · View at Scopus
  107. S. A. W. Fuqua, R. Schiff, I. Parra et al., “Estrogen receptor β protein in human breast cancer: correlation with clinical tumor parameters,” Cancer Research, vol. 63, no. 10, pp. 2434–2439, 2003. View at Google Scholar · View at Scopus
  108. E. Leygue, H. Dotzlaw, P. H. Watson, and L. C. Murphy, “Expression of estrogen receptor β,β2, and β5 messenger RNAs in human breast tissue,” Cancer Research, vol. 59, no. 6, pp. 1175–1179, 1999. View at Google Scholar
  109. M. Maggiolini, A. G. Recchia, A. Carpino et al., “Oestrogen receptor β is required for androgen-stimulated proliferation of LNCaP prostate cancer cells,” Journal of Molecular Endocrinology, vol. 32, no. 3, pp. 777–791, 2004. View at Publisher · View at Google Scholar · View at Scopus
  110. A. Ström, J. Hartman, J. S. Foster, S. Kietz, J. Wimalasena, and J. -Å. Gustafsson, “Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 6, pp. 1566–1571, 2004. View at Publisher · View at Google Scholar · View at PubMed
  111. N. A.C.S. Wong, R. D.G. Malcomson, D. I. Jodrell, N. P. Groome, D. J. Harrison, and P. T.K. Saunders, “ERβ isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates,” Journal of Pathology, vol. 207, no. 1, pp. 53–60, 2005. View at Publisher · View at Google Scholar · View at PubMed
  112. A. Bardin, N. Boulle, G. Lazennec, F. Vignon, and P. Pujol, “Loss of ERβ expression as a common step in estrogen-dependent tumor progression,” Endocrine-Related Cancer, vol. 11, no. 3, pp. 537–551, 2004. View at Publisher · View at Google Scholar
  113. K. Pettersson, F. Delaunay, and J. A. Gustafsson, “Estrogen receptor β acts as a dominant regulator of estrogen signaling,” Oncogene, vol. 19, no. 43, pp. 4970–4978, 2000. View at Google Scholar · View at Scopus
  114. A. D. Elkin and C. D. Jacobs, “Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases,” Journal of Cancer Research and Clinical Oncology, vol. 134, no. 10, pp. 1151–1153, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  115. A. Shadaba, M. N. Gaze, and H. R. Grant, “The response of adenoid cystic carcinoma to tamoxifen,” Journal of Laryngology and Otology, vol. 111, no. 12, pp. 1186–1189, 1997. View at Google Scholar · View at Scopus
  116. D. Sharma, N. K. Saxena, N. E. Davidson, and P. M. Vertino, “Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctve corepressor complexes,” Cancer Research, vol. 66, no. 12, pp. 6370–6378, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  117. T. Yoshimura, T. Sumida, S. Liu et al., “Growth inhibition of human salivary gland tumor cells by introduction of progesterone (Pg) receptor and Pg treatment,” Endocrine-Related Cancer, vol. 14, no. 4, pp. 1107–1116, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  118. M. A. Lopes, G. C. Santos, and L. P. Kowalski, “Multivariate survival analysis of 128 cases of oral cavity minor salivary gland carcinomas,” Head and Neck, vol. 20, no. 8, pp. 699–706, 1998. View at Publisher · View at Google Scholar · View at Scopus
  119. A. S. Jones, J. W. Hamilton, H. Rowley, D. Husband, and T. R. Helliwell, “Adenoid cystic carcinoma of the head and neck,” Clinical Otolaryngology and Allied Sciences, vol. 22, no. 5, pp. 434–443, 1997. View at Google Scholar · View at Scopus
  120. R. H. Spiro, “Distant metastasis in adenoid cystic carcinoma of salivary origin,” American Journal of Surgery, vol. 174, no. 5, pp. 495–496, 1997. View at Publisher · View at Google Scholar · View at Scopus
  121. D. Takagi, S. Fukuda, Y. Furuta et al., “Clinical study of adenoid cystic carcinoma of the head and neck,” Auris Nasus Larynx, vol. 28, supplement, pp. S99–S102, 2001. View at Publisher · View at Google Scholar · View at Scopus
  122. P. Marandas, D. Dharkar, A. Davis et al., “Malignant tumours of the parotid: a study of 76 patients,” Clinical Otolaryngology and Allied Sciences, vol. 15, no. 2, pp. 103–109, 1990. View at Google Scholar · View at Scopus