TY - JOUR A2 - Carrie, Sean AU - Rouby, Catherine AU - Thomas-Danguin, Thierry AU - Vigouroux, Michel AU - Ciuperca, Gabriela AU - Jiang, Tao AU - Alexanian, Jérôme AU - Barges, Mathieu AU - Gallice, Isabelle AU - Degraix, Jean-Louis AU - Sicard, Gilles PY - 2011 DA - 2011/10/20 TI - The Lyon Clinical Olfactory Test: Validation and Measurement of Hyposmia and Anosmia in Healthy and Diseased Populations SP - 203805 VL - 2011 AB - The LCOT is a self-administered test designed to assess olfactory deficits. Altogether, 525 subjects contributed to the validation. Elderly participants were well represented in this sample. In a validation study (study 1), 407 healthy and 17 anosmic volunteers between 15 and 91 years of age underwent threshold, supraliminal detection, and identification testing. Cutoff values for normosmia and hyposmia were calculated and applied in a second study in a group of patients with smell complaints and in a group of Alzheimer patients with age-matched controls. Incidence of smell deficit was estimated at 5.6% in the healthy population of study 1, and at 16% in the elderly control group of study 2. Assessment of the ability of each subtest to discriminate between groups showed that LCOT is relevant to differentiating between perception and identification deficits and between Alzheimer's and hyposmic patients. SN - 1687-9201 UR - https://doi.org/10.1155/2011/203805 DO - 10.1155/2011/203805 JF - International Journal of Otolaryngology PB - Hindawi Publishing Corporation KW - ER -