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International Journal of Otolaryngology
Volume 2013, Article ID 765265, 5 pages
Clinical Study

Goiter and Laryngeal Sensory Neuropathy

1Department of Otolaryngology-Head & Neck Surgery, American University of Beirut Medical Center, P.O. Box 110-236, Beirut, Lebanon
2Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut Medical Center, P.O. Box 110-236, Beirut, Lebanon

Received 19 February 2013; Revised 25 April 2013; Accepted 25 April 2013

Academic Editor: Bill Yates

Copyright © 2013 Abdul Latif Hamdan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Examining the prevalence of laryngeal sensory neuropathy (LSN) in goiter patients versus a control group. Study Design. Cross-sectional study. Methods. 33 Goiter patients were enrolled versus 25 age-matched controls. TSH levels, size of thyroid gland, and presence or absence of thyroid nodules were reported. Subjects were asked about the presence or absence of any of the following symptoms: cough, globus pharyngeus, and/or throat clearing that persistented for more than 6 weeks. The presence of one or more of these symptoms for at least six weeks in the absence of LPRD, allergy, asthma, ACE inhibitor intake, and psychogenic disorder was defined as LSN. Results. For goitrous patients mean age (years) was ( ) versus ( ) for controls. 82% goitrous patients had known nodules and 27% carried a simultaneous diagnosis of hypothyroidism. Among those with documented size (61%), mean total thyroid volume was  cm3, with a range from 9.430 to 67.022 cm3. The overall prevalence of LSN among goitrous patients was 42% versus 12% among controls ( ). There was no correlation between LSN, size of thyroid gland, and TSH level. Conclusion. The prevalence of LSN in goitrous patients is significantly higher than that in a nongoitrous population.