Review Article | Open Access
Henri Traboulsi, Elie Alam, Usamah Hadi, "Changing Trends in the Management of Epistaxis", International Journal of Otolaryngology, vol. 2015, Article ID 263987, 7 pages, 2015. https://doi.org/10.1155/2015/263987
Changing Trends in the Management of Epistaxis
Epistaxis is a very common complaint seen by many types of physicians including otolaryngologists, family physicians, and others. Management of epistaxis is often challenging and requires many types of intervention. The following review describes the different types of past and current treatment modalities including cautery, nasal packing, maxillary artery ligation, anterior artery ligation, and sphenopalatine artery ligation. The paper also proposes an algorithm for managing such cases.
Epistaxis is one of the commonest presenting symptoms to ENT physicians as well as to family and emergency physicians. It is thought to affect 10–12% of the population, of which 10% require medical attention . Although most cases are self-limited, some do not resolve without intervention. New treatment options and approaches have developed in the past decade, especially with the advent of nasal endoscopy. The purpose of this paper is to review the different currently available treatment modalities for the management of epistaxis and to propose a comprehensive yet simple and modern algorithm for the treatment of epistaxis. The treatment options will be divided into medical, nonsurgical interventional, and surgical options and will be described along with their advantages, disadvantages, complications, and success/failures rates. The proposed algorithm will argue for an earlier role for surgical intervention with endoscopic ligation of the sphenopalatine artery (ESPAL) in view of recent literature regarding its efficacy, safety, and cost-effectiveness.
2. Medical Treatment
Topical decongestants are widely available, and their limited side effect profile makes them a convenient first-line therapy for the treatment of epistaxis. Chart reviews revealed that the use of topical oxymetazoline can be successful in treating posterior epistaxis in the emergency setting in up to 65–75% of cases [2, 3]. They are, however, to be used with caution in hypertensive patients, especially when anxious patients with profuse epistaxis might have significantly elevated blood pressure in the acute setting. Another concern is the drug inability to reach its target areas when the nasal cavity is filled with blood.
Recently, a randomized control trial published by Zahed et al. compared the application of topical tranexamic acid (a drug used for patients with hereditary hemorrhagic telangiectasia) with the use of anterior packing for cases of anterior epistaxis presenting to the emergency department . The study showed that the drug was more efficacious and resulted in more rapid discharge from the emergency department and higher satisfaction rates from patients. A more recent review, however, argued that there is insufficient evidence to date for the use of tranexamic acid in stable patients with spontaneous epistaxis .
3. Nonsurgical Interventions
3.1. Warm Water Irrigation
When nasal packing products came into the market, along with the advent of nasal endoscopy and endoscopic procedures, the technique of warm water irrigation fell out of favor . But later, in 1999, a study by Stangerup et al. showed that warm water irrigation was more effective than nasal packing for the control of posterior epistaxis (55% success rate compared to 44%, resp.) . A more recent article by Novoa and Schlegel-Wagner reports a success rate of 82% in cases of intractable posterior epistaxis with no complications . The group utilize this technique as a first-line treatment for cases of posterior epistaxis. They describe the insertion of a modified bladder catheter that seals the choanae through which water at 50°C will be irrigated with the help of a caloric stimulator and will exit the catheter through a hole proximal to the inflated balloon. It is believed that the warm water causes edema of the nasal mucosa thereby compressing the bleeding vessels in addition to possibly stimulating the coagulation cascade .
3.2. Cautery via Anterior Rhinoscopy
Initial evaluation of a patient with epistaxis with anterior rhinoscopy might often reveal the source of the bleed if indeed this bleed is anterior.
Cautery options include chemical (with silver nitrate) and electric bipolar cautery. Since chemical cautery is less costly, easier to perform, and more readily available, it is more commonly used, especially by the non-ENT physician. The main risk of this procedure is septal perforation, which increases with bilateral cautery on opposing sides .
A recent chart review performed by Shargorodsky et al. reported that 77.1% of anterior epistaxis cases in their case review were treated with silver nitrate cautery with a 79% success rate on the first trial .
3.3. Nasal Packing
Nasal packing is often an effective and simple means of stopping nasal bleeds. The wide availability of packs, ease of use by nonspecialists, and low cost make this option a valid one as a first-line treatment.
However, nasal packing can be quite uncomfortable and may be responsible for a plethora of complications and adverse effects. Some of these can fortunately be mild and self-limited such as eustachian tube dysfunction, epiphora, and vasovagal reactions during insertion of the pack [11–17]. More importantly, nasal packing can also induce local infections of the nasal cavity and vestibule or can result in more extensive regional infections such as sinusitis and orbital cellulitis [18–21]. A nasal cavity giant pyogenic granuloma has also been described following nasal packs insertion . Rarely, these infections can result in more severe and potentially lethal systemic responses such as toxic shock syndrome and infectious endocarditis . The pressure effect caused by the presence of nasal packs can result in significant complications such as septal abscesses and perforations as well as necrosis of the inferior turbinates  and the nasal alae. Fracture of the lamina papyracea and perforation of the palatehave also been described. The presence of the nasal packs has been also shown to disturb normal cardiopulmonary functions and can cause bradycardia and hypoxia . Less commonly, nasal packs can be dislodged from the nasal cavity into the oropharynx resulting in a life-threatening upper airway obstruction [11, 12]. A case of cerebrospinal fluid leak was also reported following the application of a RapidRhino inflatable balloon pack . These severe complications are fortunately rare, but the overall complication rate of nasal packing has been reported to be up to 69% .
The failure rate of nasal packing has been reported to be up to 52% , and the rate of rebleeding is increased to 70% in patients with bleeding disorders . The traumatic insertion of nasal packs can also cause bleeding in areas different from the one responsible for the primary bleed . These complications and high failure rates make the insertion of nasal packs an extremely unpleasant and often dangerous option for the control of epistaxis.
In an attempt to avoid complications during surgery, angiographic embolization for treating posterior epistaxis has first been described in 1974 . The success of this procedure has been classically reported to be 71–95% . In a recent study comprising 70 patients who underwent angiographic embolization of the sphenopalatine artery, 13% had recurring bleeds within 6 weeks of the procedure and another 14% at a later presentation .
The complications of this procedure have been extensively reported in the literature and include hemiplegia, ophthalmoplegia, facial paralysis/paresthesia, blindness, or other neurological deficits caused by accidental embolization of cerebral arteries [18, 32, 33]. These possible complications were shown to occur in up to 27% of cases [18, 20].
Interestingly, some authors advocate embolization of the internal maxillary artery instead of the sphenopalatine artery in children under the age of 10 . Due to these relatively high failure rates and the introduction of the less risky and more successful endoscopic procedures, some advocate the use of angiographic embolization only when endoscopic procedures have failed or are contraindicated [21, 35, 36].
4. Surgical Intervention
4.1. Maxillary Artery Ligation
In 1965, Chandler and Serrins described the transantral ligation of the maxillary artery under local anesthesia . This technique is classically performed through the Caldwell-Luc approach.
It has been associated with persistent pain in the upper teeth, infraorbital neuralgia, oroantral fistula, sinusitis, potential damage to sphenopalatine ganglion and vidian nerve, and, rarely, blindness . Complications of this approach have been estimated to reach 28% .
Chandler and Serrins reported no failures in all 21 patients . A more recent review of the failures of this technique was published in 1988 and reported 15 failures out of 100 patients who underwent the procedure . The authors attributed these failures to the inability to properly locate the IMA and the inability to clip the branches of the internal maxillary artery to the pterygopalatine fossa.
Due to this somewhat invasive approach and potential complications, the transantral ligation of the maxillary artery technique has lost popularity, especially with the advent of the endoscopic procedures.
Ligation of the external carotid artery has also been described for refractory epistaxis; however, its failure was found to be quite high (45%) in a retrospective study conducted in 1992 .
4.2. Anterior Ethmoid Artery Ligation
The ligation of the anterior ethmoid artery has first been described through a Lynch incision in 1946 . The advances in endoscopic procedures facilitated the development of the endoscopic ligation of this technique. In a recent study , a cadaveric dissection examined the feasibility of the procedure as well as the surgical anatomy of the anterior ethmoid artery, which was correctly identified in 98.5% of cases.
A study conducted in 2006 suggested the use of endoscopic anterior ethmoid artery ligation only when the artery is in a mesentery and is clearly visible (present in 20% of cases according to the study). Otherwise, the authors rather suggested an external approach .
The surgeon should be familiar with the anatomy of the anterior ethmoid artery and should recognize its intraorbital and ethmoid components in order to properly identify it intraoperatively and to avoid complications, such as bleeding and CSF leak [45, 46]. Interestingly, the anterior ethmoid artery has also been considered to be one of the landmarks for the cranial base . Other reported complications include scarring, edema, facial ecchymosis, and damage to the medial canthal ligament .
4.3. Endoscopic Nasal Cautery
Cautery under endoscopic vision is another option for the control of epistaxis that may avoid the uncomfortable insertion of nasal packs in the case of an unidentified bleeder. While this can be performed in the operating room, a well-equipped clinic or emergency department can also be adequate settings for this procedure. While some authors report a very high success rate , others report a relatively significant risk of failure (17–33%) , which may be due to the fact that cauterizing the nasal mucosa may also damage an area that will bleed persistently.
Additionally, nasal cautery for epistaxis has been associated with palatal numbness  as well as thermal damage to neural structures, obstruction of the nasolacrimal duct, and trauma of the optic nerve, especially if the patient has previously undergone ethmoidectomy .
Cautery of the bleeding nasal mucosa seems to be simple and effective means of epistaxis control; however, the restricted availability of endoscopes and endoscopic surgeons in small centers limits the use of this technique.
4.4. Endoscopic Ligation of the Sphenopalatine Artery
The ESPAL was first described over 20 years ago . Interrupting the blood flow in a sufficiently distal area provides an advantage over the previously described techniques by avoiding the possible revascularization from the internal maxillary artery .
Despite being a relatively simple procedure, the endoscopic surgeon should have a good knowledge of the technique and the anatomy of the sphenopalatine artery (SPA) as well as the possible anatomical variations in order to achieve a successful surgery. The SPA is an end branch of the internal maxillary artery and enters the nasal cavity through the sphenopalatine foramen at the posterior lateral nasal wall (Figure 1). It is anteriorly bounded by the crista ethmoidalis, an apparently flawless bony anatomical landmark during surgery [51, 52], which is often taken down to better expose the artery. When the latter or its branches are properly identified, they can be either cauterized or clipped. A study of 67 patients by Nouraei et al. concluded that diathermy is more efficacious than ligation and that not using diathermy was an independent risk factor for failure of the procedure .
The branching patterns of the SPA have been extensively studied. It may form two, three, or even four branches [54–56]. However, it appears that two branches are almost consistently present: the posterior lateral nasal artery and the nasal septal branch [54, 55]. Moreover, it seems that the location of the sphenopalatine foramen itself is also variable, for which a classification has been proposed by Wareing and Padgham .
If performed correctly in the hands of an experienced endoscopic surgeon, the success rate of this procedure approaches 95–100% [18, 21, 51, 57]. Other authors report a failure rate of 5–10% [39, 58] and early failures are attributed by some to the release of clips or to the failure of identification and clipping of all branches  (Figure 2).
The study by Nouraei et al., however, revealed a 90% efficacy rate at 5 years for SPA diathermy. It has also shown that the complication rate has not been associated with any predictive data, such as bilateral surgery, surgery for nasal polyps, or concomitant septoplasty.
A systematic review by Kumar et al. showed that ligation of the SPA and cautery were efficacious in 98% and 100%, respectively .
5. Discussion of the Proposed Algorithm
The traditional approach to manage patients with intractable epistaxis is to rely on surgery as a last-line treatment once all conservative and nonsurgical treatments (such as nasal packing) have failed. The ease of use of ESPAL technique, its high success rate, and low complication rates have led some authors to propose revision of this management strategy and an earlier deployment of ESPAL. During the past decade, there has been interest in the literature in comparing the cost-effectiveness of ESPAL with other treatment strategies.
A prospective randomized trial by Moshaver et al. in 2004 compared treatment costs of ESPAL with conventional packing. Their reported calculated costs were $5,133 and $12,213, respectively .
Additionally, Dedhia et al. conducted a review study in 2013 to determine event probabilities while comparing current practice algorithms (initial nasal pack insertion for 3 days) and first-line ESPAL . Taking into account costs of the respective procedures and the management of recurrences, the authors concluded that the traditional practice arm and first-line ESPAL cost approximately $6,450 and $8,246, respectively. Therefore, according to this study, ESPAL as a first-line treatment for epistaxis might actually be more cost-effective than traditional approaches that rely on prolonged insertion of nasal packs initially.
Similarly, a study conducted by Rudmik and Leung in 2014 compared the cost-effectiveness of ESPAL and embolization for intractable epistaxis, defined as failure of posterior nasal packing after 3 days . Taking incremental cost-effectiveness ratio (ICER) as an outcome measure and a modeling-based economic evaluation using a decision tree analysis to incorporate postprocedural outcomes, the authors concluded that embolization was more costly compared to ESPAL ($22,324.70 and $12,484.14, resp.). The time horizon of the decision tree analysis was 2 weeks, and a multivariate sensitivity analysis confirmed that this economic conclusion was correct at a 74% certainty at least.
More recently, the same group published a modeling-based simulation of a 50-year-old male with intractable epistaxis . The risk model took into account the probabilities of the complications of each intervention, in 6 laddered management algorithms, using posterior packing, embolization, and ESPAL, in different sequences. The severity of each complication was monetized. They found that all 6 laddered strategies would achieve 99% success rate after 2 interventions; however, ESPAL and embolization were more likely to succeed after a single procedure. Strategies starting with packing and ESPAL had the lower risk.
When combining the results of this risk analysis with data on cost-effectiveness, the authors advocated a laddered approach to intractable epistaxis starting with ESPAL first.
In addition to that, there are other advantages of ESPAL over embolization, which include a reduced risk of major complications (such as stroke and blindness), direct endoscopic visualization of the bleeding site, potential diagnosis of rare causes of bleeding such as neoplasms with the possibility of biopsy, an opportunity to perform a concurrent anterior ethmoid artery ligation if required, and a reported lower health care cost .
On the other hand, many patients only experience one episode of epistaxis which may never recur, while others have only mild anterior epistaxis that may only require minimal definitive intervention. It would be difficult to justify the costs and the risks of surgery for these patients.
Therefore, we suggest in our algorithm (Figure 3) treating mild cases of anterior epistaxis with traditional and conservative measures (mentioned above).
The management of posterior nasal bleeds will depend on the availability of experienced endoscopists and relevant equipment. The experienced endoscopist may be successful in treating these patients in an emergency setting, therefore avoiding the potential adverse effects of packs insertion and the potential complications and costs of surgery under general anesthesia. ESPAL can always be done after failure of this procedure.
When an endoscopist is not available, medical therapy or warm water irrigation can be attempted before posterior nasal packing. Recurrent cases, or failures of nasal packing, should be referred to an endoscopist for ESPAL. Endovascular embolization can be performed under local anesthesia and can be considered an alternative to ESPAL if patients are poor surgical candidates.
The management of epistaxis enjoys a wide range of strategies and treatment options. However, it is important to appreciate when to correctly employ the different individual interventions. It is also important to involve an experienced endoscopist when appropriate who can intervene either with endoscopic control in the emergency department or with ESPAL in the operating room. Recent literature advocates an earlier surgical intervention with ESPAL for such cases due to its simplicity, high success rate, low risks, and cost-effectiveness compared to other treatment modalities such as posterior nasal packing.
Conflict of Interests
The authors declare that there is no conflict of interests regarding the publication of this paper.
- J. G. Rockey and R. Anand, “A critical audit of the surgical management of intractable epistaxis using sphenopalatine artery ligation/diathermy,” Rhinology, vol. 40, no. 3, pp. 147–149, 2002.
- G. A. Krempl and A. D. Noorily, “Use of oxymetazoline in the management of epistaxis,” Annals of Otology, Rhinology & Laryngology, vol. 9, part 1, pp. 704–706, 1995.
- G. Doo and D. S. Johnson, “Oxymetazoline in the treatment of posterior epistaxis,” Hawaii Medical Journal, vol. 58, no. 8, pp. 210–212, 1999.
- R. Zahed, P. Moharamzadeh, S. AlizadehArasi, A. Ghasemi, and M. Saeedi, “A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial,” The American Journal of Emergency Medicine, vol. 31, no. 9, pp. 1389–1392, 2013.
- L. Hilton, “Best evidence topic reports. BET 3: topical intranasal tranexamic acid for spontaneous epistaxis,” Emergency Medicine Journal, no. 5, pp. 436–437, 2014.
- E. Novoa and C. Schlegel-Wagner, “Hot water irrigation as treatment for intractable posterior epistaxis in an out-patient setting,” The Journal of Laryngology & Otology, vol. 126, no. 1, pp. 58–60, 2012.
- S. E. Stangerup, H. Dommerby, C. Siim, L. Kemp, and J. Stage, “New modification of hot-water irrigation in the treatment of posterior epistaxis,” Archives of Otolaryngology—Head and Neck Surgery, vol. 125, no. 6, pp. 686–690, 1999.
- S. E. Stangerup, H. O. Dommerby, and T. Lau, “Hot water irrigation in the treatment of posterior epistaxis,” Ugeskrift For Læger, vol. 158, no. 27, pp. 3932–3934, 1996.
- F. Pond and A. Sizeland, “Epistaxis. Strategies for management,” Australian Family Physician, vol. 29, no. 10, pp. 933–938, 2000.
- J. Shargorodsky, B. S. Bleier, and E. H. Holbrook, “Outcomes analysis in epistaxis management: development of a therapeutic algorithm,” Otolaryngology—Head and Neck Surgery, vol. 149, no. 3, pp. 390–398, 2013.
- P. M. Middleton, “Epistaxis,” Emergency Medicine Australasia, no. 5-6, pp. 428–440, 2004.
- L. E. Pope and C. G. Hobbs, “Epistaxis: an update on current management,” Postgraduate Medical Journal, vol. 81, no. 955, pp. 309–314, 2005.
- A. Ahmed and T. J. Woolford, “Endoscopic bipolar diathermy in the management of epistaxis: an effective and cost-efficient treatment,” Clinical Otolaryngology and Allied Sciences, vol. 28, no. 3, pp. 273–275, 2003.
- M. O'Donnell, G. Robertson, and G. W. McGarry, “A new bipolar diathermy probe for the outpatient management of adult acute epistaxis,” Clinical Otolaryngology and Allied Sciences, vol. 24, no. 6, pp. 537–541, 1999.
- B. Bertrand, P. Eloy, P. Rombaux, C. Lamarque, J. B. Watelet, and S. Collet, “Guidelines to the management of epistaxis,” B-ENT, vol. 1, supplement 1, pp. 27–43, 2005.
- C. J. Kucik and T. Clenney, “Management of epistaxis,” American Family Physician, vol. 71, no. 2, pp. 305–312, 2005.
- V. Srinivasan, I. W. Sherman, and G. O'Sullivan, “Surgical management of intractable epistaxis: audit of results,” Journal of Laryngology and Otology, vol. 114, no. 9, pp. 697–700, 2000.
- D. B. Simmen, U. Raghavan, H. R. Briner, M. Manestar, P. Groscurth, and N. S. Jones, “The anatomy of the sphenopalatine artery for the endoscopic sinus surgeon,” The American Journal of Rhinology, vol. 20, no. 5, pp. 502–505, 2006.
- M. Cassano, M. Longo, E. Fiocca-Matthews, and A. M. D. Giudice, “Endoscopic intraoperative control of epistaxis in nasal surgery,” Auris Nasus Larynx, vol. 37, no. 2, pp. 178–184, 2010.
- A. G. Shah, R. J. Stachler, and J. H. Krouse, “Endoscopic ligation of the sphenopalatine artery as a primary management of severe posterior epistaxis in patients with coagulopathy,” Ear, Nose & Throat Journal, vol. 84, no. 5, pp. 296–297, 306, 2005.
- H. R. Schwartzbauer, M. Shete, and T. A. Tami, “Endoscopic anatomy of the sphenopalatine and posterior nasal arteries: implications for the endoscopic management of epistaxis,” American Journal of Rhinology, vol. 17, no. 1, pp. 63–66, 2003.
- H.-M. Lee, S. H. Lee, and S. J. Hwang, “A giant pyogenic granuloma in the nasal cavity caused by nasal packing,” European Archives of Oto-Rhino-Laryngology, vol. 259, no. 5, pp. 231–233, 2002.
- R. Moorthy, R. Anand, M. Prior, and P. M. Scott, “Inferior turbinate necrosis following endoscopic sphenopalatine artery ligation,” Otolaryngology—Head and Neck Surgery, vol. 129, no. 1, pp. 159–160, 2003.
- O. Edkins, C. T. Nyamarebvu, and D. Lubbe, “Cerebrospinal fluid rhinorrhoea after nasal packing for epistaxis: case report,” The Journal of Laryngology & Otology, vol. 126, no. 4, pp. 421–423, 2012.
- B. Agreda, Á. Urpegui, J. Ignacio Alfonso, and H. Valles, “Ligation of the sphenopalatine artery in posterior epistaxis. Retrospective study of 50 patients,” Acta Otorrinolaringologica Espanola, vol. 62, no. 3, pp. 194–198, 2011.
- B. Schaitkin, M. Strauss, and J. R. Houck, “Epistaxis: medical versus surgical therapy: a comparison of efficacy, complications, and economic considerations,” Laryngoscope, vol. 97, no. 12, pp. 1392–1396, 1987.
- A. Gallo, R. Moi, A. Minni, M. Simonelli, and M. De Vincentiis, “Otorhinolaryngology emergency unit care: the experience of a large university hospital in Italy,” Ear, Nose and Throat Journal, vol. 79, no. 3, pp. 155–160, 2000.
- A. Thakar and C. J. Sharan, “Endoscopic sphenopalatine artery ligation for refractory posterior epistaxis,” Indian Journal of Otolaryngology and Head and Neck Surgery, vol. 57, no. 3, pp. 215–218, 2005.
- J. Sokoloff, I. Wickbom, D. McDonald, F. Brahme, T. C. Goergen, and L. E. Goldberger, “Therapeutic percutaneous embolization in intractable epistaxis,” Radiology, vol. 111, no. 2, pp. 285–287, 1974.
- J. P. Bent III and B. P. Wood, “Complications resulting from treatment of severe posterior epistaxis,” Journal of Laryngology and Otology, vol. 113, no. 3, pp. 252–254, 1999.
- N. P. Christensen, D. S. Smith, S. L. Barnwell, and M. K. Wax, “Arterial embolization in the management of posterior epistaxis,” Otolaryngology—Head and Neck Surgery, vol. 133, no. 5, pp. 748–753, 2005.
- R. L. Voegels, D. C. Thomé, P. P. A. Iturralde, and O. Butugan, “Endoscopic ligature of the sphenopalatine artery for severe posterior epistaxis,” Otolaryngology—Head and Neck Surgery, vol. 124, no. 4, pp. 464–467, 2001.
- S. Seno, M. Arikata, H. Sakurai et al., “Endoscopic ligation of the sphenopalatine artery and the maxillary artery for the treatment of intractable posterior epistaxis,” American Journal of Rhinology and Allergy, vol. 23, no. 2, pp. 197–199, 2009.
- G. C. Isaacson and J. M. Monge, “Arterial ligation for pediatric epistaxis: developmental anatomy,” The American Journal of Rhinology, vol. 17, no. 2, pp. 75–81, 2003.
- D. A. Klotz, M. R. Winkle, J. Richmon, and A. S. Hengerer, “Surgical management of posterior epistaxis: a changing paradigm,” Laryngoscope, vol. 112, no. 9, pp. 1577–1582, 2002.
- R. Budrovich and R. Saetti, “Microscopic and endoscopic ligature of the sphenopalatine artery,” Laryngoscope, vol. 102, part 1, no. 12, pp. 1391–1394, 1992.
- J. R. Chandler and A. J. Serrins, “Transantral ligation of the internal maxillary artery for epistaxis,” Laryngoscope, vol. 75, pp. 1151–1159, 1965.
- B. W. Pearson, R. G. MacKenzie, and W. S. Goodman, “The anatomical basis of transantral ligation of the maxillary artery in severe epistaxis,” The Laryngoscope, vol. 79, no. 5, pp. 969–984, 1969.
- T. Kamani, S. Shaw, A. Ali, G. Manjaly, and M. Jeffree, “Sphenopalatine-sphenopalatine anastomosis: a unique cause of intractable epistaxis, safely treated with microcatheter embolization: a case report,” Journal of Medical Case Reports, vol. 1, article 125, 2007.
- R. Metson and R. Lane, “Internal maxillary artery ligation for epistaxis: an analysis of failures,” Laryngoscope, vol. 98, no. 7, pp. 760–764, 1988.
- P. Spafford and J. S. Durham, “Epistaxis: efficacy of arterial ligation and long-term outcome,” Journal of Otolaryngology, vol. 21, no. 4, pp. 252–256, 1992.
- G. Weddell, R. G. MacBeth, H. S. Sharp, and C. A. Calvert, “The surgical treatment of severe epistaxis in relation to the ethmoidal arteries,” British Journal of Surgery, vol. 33, no. 132, pp. 387–392, 1946.
- B. C. A. Filho, C. D. Pinheiro-Neto, H. F. Ramos, R. L. Voegels, and L. U. Sennes, “Endoscopic ligation of the anterior ethmoidal artery: a cadaver dissection study,” Brazilian Journal of Otorhinolaryngology, vol. 77, no. 1, pp. 33–38, 2011.
- S. R. Floreani, S. B. Nair, M. C. Switajewski, and P.-J. Wormald, “Endoscopic anterior ethmoidal artery ligation: a cadaver study,” Laryngoscope, vol. 116, no. 7, pp. 1263–1267, 2006.
- J. A. Kirchner, E. Yanagisawa, and E. S. Crelin Jr., “Surgical anatomy of the ethmoidal arteries. A laboratory study of 150 orbits,” Archives of Otolaryngology, vol. 74, pp. 382–386, 1961.
- S. Basak, C. Z. Karaman, A. Akdilli, C. Mutlu, O. Odabasi, and G. Erpek, “Evaluation of some important anatomical variations and dangerous areas of the paranasal sinuses by CT for safer endonasal surgery,” Rhinology, vol. 36, no. 4, pp. 162–167, 1998.
- W. C. Lee, P. K. M. Ku, and C. A. van Hasselt, “New guidelines for endoscopic localization of the anterior ethmoidal artery: a cadaveric study,” Laryngoscope, vol. 110, no. 7, pp. 1173–1178, 2000.
- T. J. Woolford and N. S. Jones, “Endoscopic ligation of anterior ethmoidal artery in treatment of epistaxis,” The Journal of Laryngology & Otology, vol. 114, no. 11, pp. 858–860, 2000.
- E. Vis and H. van den Berge, “Treatment of epistaxis without the use of nasal packing, a patient study,” Rhinology, vol. 49, no. 5, pp. 600–604, 2011.
- L. Wang and D. H. Vogel, “Posterior epistaxis: comparison of treatment,” Otolaryngology—Head and Neck Surgery, vol. 89, no. 6, pp. 1001–1006, 1981.
- F. G. M. Pádua and R. L. Voegels, “Severe posterior epistaxis-endoscopic surgical anatomy,” Laryngoscope, vol. 118, no. 1, pp. 156–161, 2008.
- D. D. Pothier, S. MacKeith, and R. Youngs, “Sphenopalatine artery ligation: technical note,” Journal of Laryngology and Otology, vol. 119, no. 10, pp. 810–812, 2005.
- S. A. Nouraei, T. Maani, D. Hajioff, H. A. Saleh, and I. S. Mackay, “Outcome of endoscopic sphenopalatine artery occlusion for intractable epistaxis: a 10-year experience,” Laryngoscope, vol. 117, no. 8, pp. 1452–1456, 2007.
- H. Y. Lee, H.-U. Kim, S.-S. Kim et al., “Surgical anatomy of the sphenopalatine artery in lateral nasal wall,” Laryngoscope, vol. 112, no. 10, pp. 1813–1818, 2002.
- J. M. Prades, A. Asanau, A. P. Timoshenko, M. B. Faye, and C. Martin, “Surgical anatomy of the sphenopalatine foramen and its arterial content,” Surgical and Radiologic Anatomy, vol. 30, no. 7, pp. 583–587, 2008.
- M. J. Wareing and N. D. Padgham, “Osteologic classification of the sphenopalatine foramen,” Laryngoscope, vol. 108, no. 1, part 1, pp. 125–127, 1998.
- S. Kumar, A. Shetty, J. Rockey, and E. Nilssen, “Contemporary surgical treatment of epistaxis. What is the evidence for sphenopalatine artery ligation?” Clinical Otolaryngology and Allied Sciences, vol. 28, no. 4, pp. 360–363, 2003.
- R. Midilli, M. Orhan, C. Y. Saylam, S. Akyildiz, S. Gode, and B. Karci, “Anatomic variations of sphenopalatine artery and minimally invasive surgical cauterization procedure,” American Journal of Rhinology and Allergy, vol. 23, no. 6, pp. e38–e41, 2009.
- A. Moshaver, J. R. Harris, R. Liu, C. Diamond, and H. Seikaly, “Early operative intervention versus conventional treatment in epistaxis: randomized prospective trial,” Journal of Otolaryngology, vol. 33, no. 3, pp. 185–188, 2004.
- R. C. Dedhia, S. S. Desai, K. J. Smith et al., “Cost-effectiveness of endoscopic sphenopalatine artery ligation versus nasal packing as first-line treatment for posterior epistaxis,” International Forum of Allergy & Rhinology, vol. 3, no. 7, pp. 563–566, 2013.
- L. Rudmik and R. Leung, “Cost-effectiveness analysis of endoscopic sphenopalatine artery ligation vs arterial embolization for intractable epistaxis,” JAMA Otolaryngology—Head & Neck Surgery, vol. 140, no. 9, pp. 802–808, 2014.
- R. M. Leung, T. L. Smith, and L. Rudmik, “Developing a laddered algorithm for the management of intractable epistaxis: a risk analysis,” JAMA Otolaryngology—Head & Neck Surgery, vol. 141, no. 5, pp. 405–409, 2015.
- L. Rudmik and T. L. Smith, “Management of intractable spontaneous epistaxis,” American Journal of Rhinology, vol. 26, no. 1, pp. 55–60, 2012.
Copyright © 2015 Henri Traboulsi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.