International Journal of Otolaryngology / 2015 / Article / Tab 2

Research Article

More Than One Disease Process in Chronic Sinusitis Based on Mucin Fragmentation Patterns and Amino Acid Analysis

Table 2

Amino acid composition of reduced chronic sinusitis mucins.

Amino acidS1S2S3S4S5S6S7S8
MUC5AC rich samplesMUC2 rich samples
% content of amino acids% content of amino acids

His 3.8 ± .0.71.6 ± 0.42.1 ± 0.15.5 ± 0.47.8 ± 0.72.3 ± 0.33.5 ± 0.11.5 ± 0.3
Arg20.4 ± 1.413.2 ± 1.77.2 ± 0.59.7 ± 0.74.2 ± 0.29.9 ± 1.05.9 ± 0.47.3 ± 0.7
Ser27.9 ± 0.112.4 ± 1.322.5 ± 1.514.3 ± 0.711.1 ± 1.127.8 ± 0.825.5 ± 1.618.6 ± 1.6
Thr30.6 ± 0.525.4 ± 2.432.9 ± 1.225.8 ± 2.121.2 ± 0.219.4 ± 1.217.8 ± 0.89.4 ± 0.4
Asp32.4 ± 0.419.7 ± 1.630.5 ± 2.220.6 ± 0.611.2 ± 0.37.2 ± 0.24.9 ± 0.420.2 ± 1.6
Glu9.6 ± 1.49.8 ± 0.221.2 ± 1.211.1 ± 1.017.2 ± 0.28.2 ± 1.38.3 ± 0.34.5 ± 0.6
Gly5.7 ± 1.26.8 ± 0.417.0 ± 1.314.5 ± 0.83.4 ± 0.26.6 ± 0.67.0 ± 0.21.0 ± 0.1
Ala25.2 ± 1.022.0 ± 2.224.2 ± 1.124.2 ± 1.95.8 ± 0.814.7 ± 1.215.4 ± 1.510.7 ± 0.1
Pro26.5 ± 2.727.9 ± 0.924.8 ± 2.216.1 ± 1.7 9.5 ± .0.524.2 ± 1.211.3 ± 0.211.4 ± 0.3
Val4.6 ± 0.63.4 ± 0.69.1 ± 0.13.7 ± 0.22.9 ± 0.35.3 ± 0.34.6 ± 0.81.6 ± 0.4
Ile/Leu/Phe14.6 ± 1.80.9 ± 1.511.0 ± 1.113.0 ± 1.26.9 ± 0.315.1 ± 1.320.8 ± 0.813.7 ± 1.5
Lys5.4 ± 1.05.5 ± 0.47.6 ± 1.12.6 ± 0.28.8 ± 0.22.9 ± 0.53.6 ± 0.700 ± 00
Calc. ptn206.7 ± 10.2156.7 ± 9.9210.0 ± 13.4161.1 ± 3.8110.0 ± 2.2143.6 ± 3.7128.0 ± 3.499.7 ± 7.6

The values quoted are of the % amino acid contents in reduced sinus mucins. The samples were arranged according to the proportions of the relevant predominant mucin. In the first 4 samples MUC5AC (S1–S4) was predominant and MUC2 was predominant in the other 4 samples (S5–S8). Amino acid content was calculated in quadruplicate samples and the mean content of amino acid in each sample was calculated. Calc. ptn: calculated total protein in ug/mg of freeze-dried mucin.

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