Evidence Supporting the Hypothesis That Inflammation-Induced Vasospasm Is Involved in the Pathogenesis of Acquired Sensorineural Hearing Loss

Table 2

Evidence for effectiveness of magnesium in prevention of noise-induced SNHL from randomised controlled trials in humans.

Design	Number of participants	Age of participants	Intervention	Outcome	Critical appraisal	Reference
Placebo-controlled double blind	28 participants in total, number per group unknown	22 to 75 years of age, mean 53 years	6.7 mmol of magnesium aspartate orally once a day	Improvement of sudden SNHL excluding noise, mumps, Meniere’s disease, and traumatic SNHL: more patients with improved hearing and a greater improvement in those with SSNHL were noted in the magnesium treated group across all frequencies assessed	The investigation did not report method of randomisation, number randomised into each group, and number of patients with improved hearing for each frequency	[77]
Placebo-controlled double blind	150 participants in each group	17.7 to 18.5 years old	6.7 mmol of magnesium aspartate orally once a day	Noise-induced permanent hearing threshold shifts in 11.2% in the magnesium group versus 21.5% in the placebo group ()	The method of randomisation was unclear, and the duration of prophylactic treatment and timing of measurement were not specified	[78]
Placebo-controlled double blind	215 participants, 105 in the magnesium group, and 110 in the placebo group	18-year-old men	6.7 mmol of magnesium aspartate orally once a day	There was a noise-induced pure tone audiometry threshold shift (>25 dB at 3 to 8 kHz) in 11.2% (both ears) of the magnesium group and 21.5% in the left ear and 28.5% in the right ear in the placebo group	The method of randomisation was unclear, and the duration of prophylactic treatment and timing of sampling were not specified	[79]