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International Journal of Photoenergy
Volume 4, Issue 2, Pages 51-56
http://dx.doi.org/10.1155/S1110662X02000090

The phthalocyanines applications in photodynamic therapy investigated by time-resolved and steady-state photothermal methods

1Faculty of Technical Physics, Poznań University of Technology, Nieszawska 13A, Poznań 60-965, Poland
2Department of Biology and Enviromental Studies, K. Marcinkowski University of Medical Sciences, Długa 1/2, Poznań 61-848, Poland
3ZECASIN Splaiul Independentei 202, Bucharest 79611, Romania

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The time-resolved photothermal methods are used in order to establish the yield of intersystem (singlet-triplet) crossing of dyes that are candidates for the application in photodynamic therapy. It is known that molecules with long living triplet state cause efficient photosensitization by direct interaction with the cells or by singlet oxygen generation.

The steady state photoacoustic spectra enables one to establish the dye incorporation into cells.

Both methods were applied to several phthalocyanines and the results gathered by photothermal measurements were compared with the results obtained by means of other methods.The six investigated dyes were compared.