International Journal of Photoenergy / 2014 / Article / Fig 5

Research Article

Autoregulatory Feedback Mechanism of P38MAPK/Caspase-8 in Photodynamic Therapy-Hydrophilic/Lipophilic Tetra- -(4-carboxyphenoxy) Phthalocyanine Zinc-Induced Apoptosis of Human Hepatocellular Carcinoma Bel-7402 Cells

Figure 5

Effect of TαPcZn-PDT on mitochondria of Bel-7402 cells in the absence or presence of SB203580 or Ac-IEFD-CHO. Bel-7402 cells were pretreated with TαPcZn (54 μM) in the absence or presence of SB203580 (10 μM) or Ac-IEFD-CHO (10 μM) for 2.5 h, exposed to red-light irradiation (53.7 J/cm2), and then incubated for 3 h. Expression of Cytochrome c was analyzed by immunoblot assay (a), and mitochondria membrane potential (b) and ratio of red to green fluorescence intensity (c) in Bel-7402 cells were determined by JC-1 assay of flow cytometry, respectively. Values presented are representative of three independent experiments (means ± S.D.; , compared with control treatment; , compared with TαPcZn-PDT treatment).

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