Potential Use of C₆₀/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer

Figure 1

ESR spectra of the TEMPO-OH adduct generated in a C₆₀/HP-β-CyD colloidal solution and a PpIX solution (C₆₀ and PpIX = 80 μM, light irradiation at 25 mW/cm² for 5 min) (a). Its relative intensity increment after visible light irradiation. (b) Effects of the light power (c) and concentrations of photosensitizers (d) on the generation of ¹O₂. Empty circle: C₆₀/HP-β-CyD nanoparticles; empty square: PpIX. Each point represents the mean ± S.E. of 3 experiments.^∗𝑃<0.05 versus PpIX.

(a)

(b)

(c)

(d)