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International Journal of Photoenergy
Volume 2015, Article ID 583052, 6 pages
http://dx.doi.org/10.1155/2015/583052
Research Article

Photostability of Loratadine Inclusion Complexes with Natural Cyclodextrins

Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Rua do Lago 250, Prédio Semi-Industrial, Cidade Universitária, Butantã, 05508-080 São Paulo, SP, Brazil

Received 20 October 2015; Accepted 10 December 2015

Academic Editor: Iqbal Ahmad

Copyright © 2015 Patricia Elizabeth Rivas-Granizo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to evaluate the photostability of inclusion complexes of the histamine antagonist loratadine (LORA) with -, -, and -cyclodextrins (CDs). Accordingly, binary drug-CD complexes were prepared using the coevaporation method at 1 : 1, 1 : 2, and 1 : 3 stoichiometric ratios, which were characterized by thermal analysis. Subsequently, solutions of the complexes at 500 μg mL−1 in HCl 0.1 M were subjected to irradiation in a photostability chamber for 12 hours, and the content of the remaining active ingredient was quantified by means of high-performance liquid chromatography. It is possible to observe the presence of two products originating from photodegradation (P1 and P2), which were identified in solutions of loratadine with - and -CD. By means of statistical analysis, we conclude that the drug:-CD and drug:-CD (1 : 1) complexes proved to be more efficient in the photostability assay, obtaining a nonsignificant level of degradation and full recovery of LORA.