The Use of N-Terminal-Pro-BNP in Preterm Infants

Table 3

The use of NTpBNP in PDA diagnosis. NTpBNP rises significantly in the presence of a PDA. All studies used the Roche Elecsys system. ROC: Receiver Operating Characteristics Curve; 𝑁 no PDA: number without PDA; 𝑁 PDA: Number with PDA.

Study	Gestation mean (wks)	Birth weight mean (Kg)	Day of life	𝑁 no PDA	NTpBNP (pmol/L)	𝑁 PDA	NTpBNP (pmol/L)	Cut off NTpBNP (pmol/L)	ROC (95% CI)	Sensitivity	Specificity
El-Khuffash et al. [29]	28	1.06	2	35	740	45	6046	4000	0.88 (0.79–0.96)	70%	89%
Nuntnarumit et al. [36]	30	1.30	2	23	463	12	1934	1203	0.96 (0.91–1.02)	100%	91%
Farombi et al. [37]	30	1.22	3	31	372	18	3891	1347	0.98 (0.93–1.03)	100%	95%
Ramakrishnan et al. [38]	29	1.22	2	36	1206	20	6952	2850	0.90 (0.81–0.99)	90%	89%