Recent Advances in the Pathogenesis of Syndromic Autisms

Figure 1

Genetic and epigenetic factors involved in the pathogenesis of autism. Interactions between multiple genes and environmental factors, such as intrauterine infections, alcohol/toxins exposure, and obstetrical suboptimality, can influence intrauterine and early postnatal brain development and disrupt crucial neurobiological pathways, from neuronal migration and cortical organization to synaptic and dendritic conformation, resulting in alterations of neurobehavioral trajectories that are involved in the pathogenesis of ASD.