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International Journal of Pediatrics
Volume 2009 (2009), Article ID 241376, 6 pages
http://dx.doi.org/10.1155/2009/241376
Clinical Study

Aminoterminal Pro B-Type Natriuretic Peptide (NT-proBNP) Levels for Monitoring Interventions in Paediatric Cardiac Patients with Stenotic Lesions

1Department of Paediatric Cardiology, Ruhr University Bochum, North Rhine Westphalia, 32545, Germany
2Department of Paediatrics, Children's Hospital, London Health Science Centre, University of Western Ontario, 800 Commissioners Road East London, ON, Canada N6A 5W9
3Department of Laboratory Medicine, Heart and Diabetes Centre Bad Oeynhausen, Ruhr University Bochum, North Rhine Westphalia, 32545, Germany
4Department of Paediatric Cardiology, Medical School of Hannover, Germany

Received 10 August 2009; Revised 11 October 2009; Accepted 27 December 2009

Academic Editor: Peter Oishi

Copyright © 2009 Eva Welisch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Serum concentration of NT-proBNP correlates well with the severity of cardiac disease in adults. Few studies have been performed on the applicability of NT-proBNP for monitoring children with congenital heart disease. Objective. To assess the potential of NT-proBNP for monitoring the success of interventions in children with stenotic cardiac lesions. Methods. NT-proBNP was measured in 42 children aged 1 day to 17 years (y) before and 6 to 12 weeks after surgical or interventional correction of obstructive lesions of the heart. Comparison is made with the clinical status and echocardiographic data of the child. Results. NT-proBNP levels (median 280, range 10–263,000 pg/mL) were above the reference value in all but 6 patients (pts) prior to the intervention. Higher levels were found in more compromised patients. The 35 children with clinical improvement after the procedure showed a decline of their NT-proBNP level in all but 4 patients, whose levels remained unchanged. Five patients with unchanged gradients despite a therapeutic intervention also demonstrated unchanged NT-proBNP levels after the intervention. Thus, the success rate of the procedure correlated well to clinical and echocardiographic findings. Conclusion. NT-proBNP can be used to assess the efficiency of an intervention.