International Journal of Pediatrics / 2009 / Article / Tab 6

Review Article

Pediatric Migraine

Table 6

Drugs used for prevention of migraine attacks.

ClassDrug & dosageComments

Beta blockersPropranolol 3 mg/kg/dayReduced energy, tiredness, postural symptoms, contraindicated in asthma, depressive side effects, often limits their usefulness in children

Calcium chanel blockersFlunarizine, PO, 5 mgNot available in US
NimodipineNot recommended for use in pediatric migraine

AnticonvulsantsValproate 15–45 mg/kg/day, PODrowsiness, weight gain, tremor, hair loss, fetal abnormalities,haemato-logical or liver abnormalities
Topiramate 2–3 mg/kg/day, POFound to be effective in pediatric migraine. Side effects include cognitive changes, weight loss, and sensory symptoms
Levetiracetam 250–500 mgEvaluated in pediatric migraine and found to be effective. About 10% children report somnolence, dizziness, and irritability

AntidepressentsAmitriptyline 1 mg/kg/day, POReduces headache frequency and severity; sedation major side effect
Trazodone 1 mg/kg/day, divided TID, POCurrent literature: no evidence of benifit
PizotefenCurrent literature: no evidence of benifit

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