| | Type | . | W.g. at dg. | Assoc. ECAs/ other conditions | Heart failure | Arrh. | Ther. in utero | Outcome in utero—w.g.
TP IUD Delivery | Postnatal
death | Total death of cases continuing pregn. | Alive/age |
| | “Idiop.” | 17 | | 5 familial history | — | — | — | 1 lost
11 delivered at 31-38 w.g. | 1–38 d (met.dis) | 2/16 with known f-up = 125% | 14 alive at 2–14 yrs:
3 worsened—1 Tx at 2 m;
1 operated at 3 yrs
for LVOT-mitral
tissue obstruction;
1 needing betablockers;
5 unchanged
(mild-moderate);
6 improved at 3 m–1 yr. | | | 12 no familial history | | | | | 1 prem. born at 28 w.g. died at 15 d. | |
| | Secondary to ECA | 26 | 17–30 Median 22 | 16 renal,
3 CNS,
7 (skeletal anom.,
arthrogryposis,
Thomas s.,
Noonan s.) | 3 (mild-moder.) | | | 8 TP,
6 IUD at 23–30 w.g.,
12 delivered at 28–37 w.g. | 7 (1–35 d) | 13/18 = 72.2% | 5 alive, regressed |
| | Secondary to maternal diabetes | 17 | 27–37 | 12 pregest., 5 gest. | 1 (mild) | 1 flutter | | 17 delivered at 37–39 w.g. | 2 (2 d, 4 m) | 2/17 = 11.8% | 15 alive, normalized at 3–6 m |
| | HCM total | 60 | 17–39 | | 4 (6.7%) | 1 | 1 | 8 TP,
6 IUD,
1 lost,
45 delivered | 11/51 with known f-up = 21.6% | 17/51 with known f-up = 33.3% | 34 alive,
2 worsened,
6 unchanged,
26 improved/normalized |
|
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Idiop.: idiopathic, n.: number, w.g.: weeks’ gestation, dg.: diagnosis, ECAs: extracardiac anomalies, anom.: anomalies, CNS: central nervous system, s.: syndrome, arrh.: arrhythmias, SVT: supraventricular tachycardia, ther.: therapy, dig.: digoxin, TP: termination of pregnancy, IUD: intrauterine death, d: day, m: month, yr: year, s.: syndrome, met.dis.: metabolic disease, prem.: premature, gest.: gestational, pregest.: pregestational, moder.: moderate, f-up: follow-up, Tx: heart transplant, and LVOT: left ventricular outflow tract.
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