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International Journal of Pediatrics
Volume 2011, Article ID 143872, 8 pages
http://dx.doi.org/10.1155/2011/143872
Clinical Study

Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmec Type II in Children with Impetigo in Japan

1Pediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, Japan
2Department of Pediatrics, Health Sciences University of Hokkaido, Kita-ku, Sapporo 002-8072, Japan
3Nakata Pediatric Clinic, Shiroishi-ku, Sapporo 003-0023, Japan
4Yamanaka Tatsuru Pediatrics, Shiroishi-ku, Sapporo 003-0022, Japan
5Department of Pediatrics, Asahikawa Kosei Hospital, Asahikawa 078-8211, Japan
6Department of Laboratory Medicine, Hokkaido University Medical Hospital, Kita-ku, Sapporo 060-0814, Japan
7Department of Pediatrics, Sapporo Hokuyu Hospital, Shiroishi-ku, Sapporo 003-0006, Japan

Received 10 September 2011; Revised 10 October 2011; Accepted 17 October 2011

Academic Editor: Hans Juergen Laws

Copyright © 2011 H. Kikuta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. L. Archer, “Staphylococcus aureus: a well-armed pathogen,” Clinical Infectious Diseases, vol. 26, no. 5, pp. 1179–1181, 1998. View at Google Scholar · View at Scopus
  2. M. P. Jevons, “"Celbenin"-resistant staphylococci,” British Medical Journal, vol. 1, no. 5219, pp. 124–125, 1961. View at Google Scholar
  3. F. F. Barrett, R. F. McGehee Jr., and M. Finland, “Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations,” New England Journal of Medicine, vol. 279, no. 9, pp. 441–448, 1968. View at Google Scholar · View at Scopus
  4. R. H. Deurenberg, C. Vink, S. Kalenic, A. W. Friedrich, C. A. Bruggeman, and E. E. Stobberingh, “The molecular evolution of methicillin-resistant Staphylococcus aureus,” Clinical Microbiology and Infection, vol. 13, no. 3, pp. 222–235, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Stefani and P. E. Varaldo, “Epidemiology of methicillin-resistant staphylococci in Europe,” Clinical Microbiology and Infection, vol. 9, no. 12, pp. 1179–1186, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. R. J. Gordon and F. D. Lowy, “Pathogenesis of methicillin-resistant Staphylococcus aureus infection,” Clinical Infectious Diseases, vol. 46, supplement 5, pp. S350–S359, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Hartman and A. Tomasz, “Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus,” Antimicrobial Agents and Chemotherapy, vol. 19, no. 5, pp. 726–735, 1981. View at Google Scholar · View at Scopus
  8. Y. Katayama, T. Ito, and K. Hiramatsu, “A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 6, pp. 1549–1555, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. E. E. Udo, J. W. Pearman, and W. B. Grubb, “Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia,” Journal of Hospital Infection, vol. 25, no. 2, pp. 97–108, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. H. F. Chambers, “The changing epidemiology of Staphylococcus aureus?” Emerging Infectious Diseases, vol. 7, no. 2, pp. 178–182, 2001. View at Google Scholar · View at Scopus
  11. K. Okuma, K. Iwakawa, J. D. Turnidge et al., “Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community,” Journal of Clinical Microbiology, vol. 40, no. 11, pp. 4289–4294, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Z. David and R. S. Daum, “Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic,” Clinical Microbiology Reviews, vol. 23, no. 3, pp. 616–687, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Saiman, M. O'Keefe, P. L. Graham III et al., “Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women,” Clinical Infectious Diseases, vol. 37, no. 10, pp. 1313–1319, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Valsesia, M. Rossi, S. Bertschy, and G. E. Pfyffer, “Emergence of SCCmec type IV and SCCmec type V methicillin-resistant Staphylococcus aureus containing the Panton-Valentine leukocidin genes in a large academic teaching hospital in Central Switzerland: external invaders or persisting circulators?” Journal of Clinical Microbiology, vol. 48, no. 3, pp. 720–727, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Motoshima, K. Yanagihara, Y. Morinaga et al., “Genetic diagnosis of community-acquired MRSA: a multiplex real-time PCR method for staphylococcal cassette chromosome mec typing and detecting toxin genes,” Tohoku Journal of Experimental Medicine, vol. 220, no. 2, pp. 165–170, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. E. S. Yang, J. Tan, S. Eells, G. Rieg, G. Tagudar, and L. G. Miller, “Body site colonization in patients with community-associated methicillin-resistant Staphylococcus aureus and other types of S. aureus skin infections,” Clinical Microbiology and Infection, vol. 16, no. 5, pp. 425–431, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Hisata, K. Kuwahara-Arai, M. Yamanoto et al., “Dissemination of methicillin-resistant staphylococci among healthy Japanese children,” Journal of Clinical Microbiology, vol. 43, no. 7, pp. 3364–3372, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Ozaki, M. Takano, W. Higuchi et al., “Genotypes, intrafamilial transmission, and virulence potential of nasal methicillin-resistant Staphylococcus aureus from children in the community,” Journal of Infection and Chemotherapy, vol. 15, no. 2, pp. 84–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Bukowski, B. Wladyka, and G. Dubin, “Exfoliative toxins of Staphylococcus aureus,” Toxins, vol. 2, no. 5, pp. 1148–1165, 2010. View at Publisher · View at Google Scholar
  20. S. Nishijim, S. Ohshima, T. Higashida, H. Nakaya, and I. Kurokawa, “Antimicrobial resistance of Staphylococcus aureus isolated from impetigo patients between 1994 and 2000,” International Journal of Dermatology, vol. 42, no. 1, pp. 23–25, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Yamaguchi, Y. Yokota, J. Terajima et al., “Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan,” Journal of Infectious Diseases, vol. 185, no. 10, pp. 1511–1516, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Takizawa, I. Taneike, S. Nakagawa et al., “A Panton-Valentine leucocidin (PVL)-positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more-typical PVL-negative MRSA strains found in Japan,” Journal of Clinical Microbiology, vol. 43, no. 7, pp. 3356–3363, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Hisata, T. Ito, N. Matsunaga et al., “Dissemination of multiple MRSA clones among community-associated methicillin-resistant Staphylococcus aureus infections from Japanese children with impetigo,” Journal of Infection and Chemotherapy, vol. 17, no. 5, pp. 609–621, 2011. View at Publisher · View at Google Scholar
  24. D. Shi, W. Higuchi, T. Takano et al., “Bullous impetigo in children infected with methicillin-resistant Staphylococcus aureus alone or in combination with methicillin-susceptible S. aureus: analysis of genetic characteristics, including assessment of exfoliative toxin gene carriage,” Journal of Clinical Microbiology, vol. 49, no. 5, pp. 1972–1974, 2011. View at Publisher · View at Google Scholar
  25. T. Yamamoto, S. Dohmae, K. Saito et al., “Molecular characteristics and in vitro susceptibility to antimicrobial agents, including the des-fluoro(6) quinolone DX-619, of Panton-Valentine leucocidin-positive methicillin-resistant Staphylococcus aureus isolates from the community and hospitals,” Antimicrobial Agents and Chemotherapy, vol. 50, no. 12, pp. 4077–4086, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Jarraud, C. Mougel, J. Thioulouse et al., “Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease,” Infection and Immunity, vol. 70, no. 2, pp. 631–641, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. M. C. Enright, N. P. J. Day, C. E. Davies, S. J. Peacock, and B. G. Spratt, “Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus,” Journal of Clinical Microbiology, vol. 38, no. 3, pp. 1008–1015, 2000. View at Google Scholar · View at Scopus
  28. Y. Kondo, T. Ito, X. X. Ma et al., “Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions,” Antimicrobial Agents and Chemotherapy, vol. 51, no. 1, pp. 264–274, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. Japan Society of Chemotherapy, “Method for the determination of minimum inhibitory concentration (MIC) of bacteria by microdilution method,” Chemotherapy, vol. 38, no. 1, pp. 102–105, 1990 (Japanese). View at Google Scholar
  30. Japan Society of Chemotherapy, “Method for the determination of minimum inhibitory concentration (MIC) of fastidious bacteria and anaerobic bacteria by microdilution method,” Chemotherapy, vol. 41, no. 2, pp. 183–189, 1993 (Japanese). View at Google Scholar
  31. Clinical and Laboratory Standards Institute, CLSI Approved Standard, Clinical and Laboratory Standards Institute, Wayne, Pa, USA, 8th edition, 2009.
  32. Clinical and Laboratory Standards Institute, CLSI Nineteenth Informational Supplement, M100-S19, Clinical and Laboratory Standards Institute, Wayne, Pa, USA, 2009.
  33. D. M. Livermore and D. F. Brown, “Detection of β-lactamase-mediated resistance,” Journal of Antimicrobial Chemotherapy, vol. 48, supplement 1, pp. 59–64, 2001. View at Google Scholar · View at Scopus
  34. T. Ito, K. Okuma, X. X. Ma, H. Yuzawa, and K. Hiramatsu, “Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC,” Drug Resistance Updates, vol. 6, no. 1, pp. 41–52, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Noguchi, H. Nakaminami, S. Nishijima, I. Kurokawa, H. So, and M. Sasatsu, “Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome,” Journal of Clinical Microbiology, vol. 44, no. 6, pp. 2119–2125, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Nakaminami, N. Noguchi, M. Ikeda et al., “Molecular epidemiology and antimicrobial susceptibilities of 273 exfoliative toxin-encoding-gene-positive Staphylococcus aureus isolates from patients with impetigo in Japan,” Journal of Medical Microbiology, vol. 57, no. 10, pp. 1251–1258, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Liu, F. Kong, X. Zhang, M. Brown, L. Ma, and Y. Yang, “Antimicrobial susceptibility of Staphylococcus aureus isolated from children with impetigo in China from 2003 to 2007 shows community-associated methicillin-resistant Staphylococcus aureus to be uncommon and heterogeneous,” British Journal of Dermatology, vol. 161, no. 6, pp. 1347–1350, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. I.-G. Bae, G. T. Tonthat, M. E. Stryjewski et al., “Presence of genes encoding the Panton-Valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational trial,” Journal of Clinical Microbiology, vol. 47, no. 12, pp. 3952–3957, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Lina, Y. Piémont, F. Godail-Gamot et al., “Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia,” Clinical Infectious Diseases, vol. 29, no. 5, pp. 1128–1132, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Akiyama, O. Yamasaki, J. Tada, and J. Arata, “Adherence characteristics and susceptibility to antimicrobial agents of Staphylococcus aureus strains isolated from skin infections and atopic dermatitis,” Journal of Dermatological Science, vol. 23, no. 3, pp. 155–160, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Daskalaki, P. Rojo, M. Marin-Ferrer, M. Barrios, J. R. Otero, and F. Chaves, “Panton-Valentine leukocidin-positive Staphylococcus aureus skin and soft tissue infections among children in an emergency department in Madrid, Spain,” Clinical Microbiology and Infection, vol. 16, no. 1, pp. 74–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC), “Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements,” Antimicrobial Agents and Chemotherapy, vol. 53, no. 12, pp. 4961–4967, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. W. Higuchi, S. Mimura, Y. Kurosawa et al., “Emergence of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in a Japanese child, demonstrating multiple divergent strains in Japan,” Journal of Infection and Chemotherapy, vol. 16, no. 4, pp. 292–297, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Chheng, S. Tarquinio, V. Wuthiekanun et al., “Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia,” Public Library of Science One, vol. 4, no. 8, p. e6630, 2009. View at Google Scholar
  45. T. Yamamoto, A. Nishiyama, T. Takano et al., “Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance,” Journal of Infection and Chemotherapy, vol. 16, no. 4, pp. 225–254, 2010. View at Publisher · View at Google Scholar · View at Scopus