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International Journal of Pediatrics
Volume 2011, Article ID 217564, 5 pages
http://dx.doi.org/10.1155/2011/217564
Research Article

Management and Outcome in 32 Neonates with Thrombotic Events

1Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands
2Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands
3Division of Immunology and Hemato-Oncology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands
4Department of Radiology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Received 30 May 2011; Accepted 30 June 2011

Academic Editor: Namık Yaşar Özbek

Copyright © 2011 H. A. van Elteren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage ( ) and abscess at the injection site ( ). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis.