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International Journal of Pediatrics
Volume 2011, Article ID 219268, 7 pages
Clinical Study

Cardiometabolic Biomarkers in Young Black Girls: Relations to Body Fatness and Aerobic Fitness, and Effects of a Randomized Physical Activity Trial

1Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University (Formerly the Medical College of Georgia), Augusta, GA 30912, USA
2Department of Nutrition, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA
3School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA
4Department of Biostatistics, Georgia Health Sciences University, Augusta, GA 30912, USA

Received 30 June 2011; Accepted 8 August 2011

Academic Editor: Edward Y. Lee

Copyright © 2011 Bernard Gutin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is little evidence from randomized trials showing that physical activity alone influences biomarker profiles in youths. This study tested two hypotheses: (i) that elevated body fatness and poor fitness would be associated with unfavorable levels of cardiometabolic biomarkers in 8–12-y-old black girls (n=242) and (ii) that a 10-mo PA intervention would have favorable effects on the fatness-related cardiometabolic biomarkers. At baseline, all fatness indices (i.e., percent body fat, visceral adipose tissue, BMI, and waist circumference) were significantly (P<0.05) associated with unfavorable levels of insulin, glucose, systolic BP, diastolic BP, triglycerides, C-reactive protein (CRP), and fibrinogen. Aerobic fitness was significantly (P<0.05) associated with favorable levels of insulin, CRP, fibrinogen, and HDL2. The PA intervention had significant and favorable effects on fitness, fatness, and two biomarkers—resting heart rate and LDL cholesterol. More research is needed to clarify what types of interventions can enhance the cardiometabolic health of youths.