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International Journal of Pediatrics
Volume 2011 (2011), Article ID 825123, 8 pages
http://dx.doi.org/10.1155/2011/825123
Clinical Study

Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition

1Medical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, Gambia
2Department of Paediatrics, University of Calabar teaching Hospital, PMB 1278, Calabar, Cross River State, Nigeria

Received 31 March 2011; Accepted 19 May 2011

Academic Editor: Sunit C. Singhi

Copyright © 2011 Uduak A. Okomo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Manary and H. L. Sandige, “Management of acute moderate and severe childhood malnutrition,” BMJ, vol. 337, p. a2180, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. E. Black, S. Cousens, H. L. Johnson et al., “Global, regional, and national causes of child mortality in 2008: a systematic analysis,” The Lancet, vol. 375, no. 9730, pp. 1969–1987, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Prudhon, Z. W. Prinzo, A. Briend, B. M. Daelmans, and J. B. Mason, “Proceedings of the WHO, UNICEF, and SCN Informal Consultation on Community-Based Management of Severe Malnutrition in Children,” Food and Nutrition Bulletin, vol. 27, no. 3, pp. S99–S104, 2006. View at Google Scholar · View at Scopus
  4. F. E. Berkowitz, “Infections in children with severe protein-energy malnutrition,” Annals of Tropical Paediatrics, vol. 3, no. 2, pp. 79–83, 1983. View at Google Scholar · View at Scopus
  5. F. E. Berkowitz, “Bacteremia in hospitalized Black South African children. A one-year study emphasizing nosocomial bacteremia and bacteremia in severely malnourished children,” American Journal of Diseases of Children, vol. 138, no. 6, pp. 551–556, 1984. View at Google Scholar · View at Scopus
  6. I. R. Friedland, “Bacteraemia in severely malnourished children,” Annals of Tropical Paediatrics, vol. 12, no. 4, pp. 433–440, 1992. View at Google Scholar · View at Scopus
  7. K. H. Brown, R. H. Gilman, A. Gaffar et al., “Infections associated with severe protein-calorie malnutrition in hospitalized infants and children,” Nutrition Research, vol. 1, no. 1, pp. 33–46, 1981. View at Google Scholar · View at Scopus
  8. WHO, Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers, World Health Organization, Geneva, Switzerland, 1998.
  9. WHO, Management of the Child with a Serious Infection or Severe Malnutrirtion: Guidelines at the First Referral Level in Developing Countries, World Health Organization, Geneva, Switzerland, 2000.
  10. P. C. Hill, C. O. Onyeama, U. N. A. Ikumapayi et al., “Bacteraemia in patients admitted to an urban hospital in West Africa,” BMC Infectious Diseases, vol. 7, article 2, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. R. A. Adegbola, P. C. Hill, O. Secka et al., “Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996–2003,” Tropical Medicine and International Health, vol. 11, no. 7, pp. 1128–1135, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. E. E. Ekanem, A. B. Umotong, C. Raykundalia, and D. Catty, “Serum C-reactive protein and C3 complement protein levels in severely malnourished Nigerian children with and without bacterial infections,” Acta Paediatrica, vol. 86, no. 12, pp. 1317–1320, 1997. View at Google Scholar · View at Scopus
  13. E. Babirekere-Iriso, P. Musoke, and A. Kekitiinwa, “Bacteraemia in severely malnourished children in an HIV-endemic setting,” Annals of Tropical Paediatrics, vol. 26, no. 4, pp. 319–328, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Bachou, T. Tylleskär, D. H. Kaddu-Mulindwa, and J. K. Tumwine, “Bacteraemia among severely malnourished children infected and uninfected with the human immunodeficiency virus-1 in Kampala, Uganda,” BMC Infectious Diseases, vol. 6, article 160, 2006. View at Publisher · View at Google Scholar
  15. J. A. Berkley, K. Maitland, I. Mwangi et al., “Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study,” British Medical Journal, vol. 330, no. 7498, pp. 995–999, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Noorani, W. M. Macharia, D. Oyatsi, and G. Revathi, “Bacterial isolates in severely malnourished children at Kenyatta National Hospital, Nairobi,” East African Medical Journal, vol. 82, no. 7, pp. 343–348, 2005. View at Google Scholar · View at Scopus
  17. D. Shimeles and S. Lulseged, “Clinical profile and pattern of infection in Ethiopian children with severe protein-energy malnutrition,” East African Medical Journal, vol. 71, no. 4, pp. 264–267, 1994. View at Google Scholar · View at Scopus
  18. R. P. Reed, F. O. Wegerhoff, and A. D. Rothberg, “Bacteraemia in malnourished rural African children,” Annals of Tropical Paediatrics, vol. 16, no. 1, pp. 61–68, 1996. View at Google Scholar · View at Scopus
  19. J. N. Scragg and P. C. Appelbaum, “Septicaemia in Kwashiorkor,” South African Medical Journal, vol. 53, no. 10, pp. 358–360, 1978. View at Google Scholar · View at Scopus
  20. I. Ighogboja and H. Okuonghae, “Infection in severely malnourished children,” Nigerian Medical Practitioner, vol. 26, pp. 27–30, 1993. View at Google Scholar
  21. G. A. Oyedeji, “The pattern of infections in children with severe protein energy malnutrition,” Nigerian Journal of Pediatrics, vol. 16, pp. 55–61, 1989. View at Google Scholar
  22. C. D. C. Christie, G. T. Heikens, and M. H. N. Golden, “Coagulase-negative staphylococcal bacteremia in severely malnourished Jamaican children,” Pediatric Infectious Disease Journal, vol. 11, no. 12, pp. 1030–1036, 1992. View at Google Scholar · View at Scopus
  23. R. A. Adegbola, O. Secka, G. Lahai et al., “Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with a Hib conjugate vaccine: a prospective study,” The Lancet, vol. 366, no. 9480, pp. 144–150, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Thame, C. Stephen, R. Wilks, and T. E. Forrester, “The appropriateness of the current antibiotic empiric therapy based on the bacteria isolated from severely malnourished Jamaican children,” West Indian Medical Journal, vol. 50, no. 2, pp. 140–143, 2001. View at Google Scholar · View at Scopus
  25. S. Y. Huang, R. B. Tang, S. J. Chen, and R. L. Chung, “Coagulase-negative staphylococcal bacteremia in critically ill children: risk factors and antimicrobial susceptibility,” Journal of Microbiology, Immunology and Infection, vol. 36, no. 1, pp. 51–55, 2003. View at Google Scholar · View at Scopus
  26. K. J. Nathoo, S. Chigonde, M. Nhembe, M. H. Ali, and P. R. Mason, “Community-acquired bacteremia in human immunodeficiency virus-infected children in Harare, Zimbabwe,” Pediatric Infectious Disease Journal, vol. 15, no. 12, pp. 1092–1097, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. S. E. Beekmann, D. J. Diekema, and G. V. Doern, “Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures,” Infection Control and Hospital Epidemiology, vol. 26, no. 6, pp. 559–566, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. L. V. Kirchhoff and J. N. Sheagren, “Epidemiology and clinical significance of blood cultures positive for coagulase-negative staphylococcus,” Infection Control, vol. 6, no. 12, pp. 479–486, 1985. View at Google Scholar · View at Scopus
  29. N. C. Bodonaik and S. Moonah, “Coagulase negative staphylococci from blood cultures contaminants or pathogens?” West Indian Medical Journal, vol. 55, no. 3, pp. 174–182, 2006. View at Google Scholar · View at Scopus
  30. A. J. Brent, J. O. Oundo, I. Mwangi, L. Ochola, B. Lowe, and J. A. Berkley, “Salmonella bacteremia in Kenyan children,” Pediatric Infectious Disease Journal, vol. 25, no. 3, pp. 230–236, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. S. M. Graham, A. L. Walsh, E. M. Molyneux, A. J. Phiri, and M. E. Molyneux, “Clinical presentation of non-typhoidal Salmonella bacteraemia in Malawian children,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 94, no. 3, pp. 310–314, 2000. View at Google Scholar · View at Scopus
  32. C. R. Banapurmath and S. Jayamony, “Prevalence of urinary tract infection in severely malnourished preschool children,” Indian Pediatrics, vol. 31, no. 6, pp. 679–682, 1994. View at Google Scholar · View at Scopus
  33. O. G. Brooke and D. S. Kerr, “The importance of routine urine culture in malnourished children,” Journal of Tropical Pediatrics and Environmental Child Health, vol. 19, no. 3 B, pp. 348–349, 1973. View at Google Scholar · View at Scopus
  34. A. I. Rabasa and D. Shattima, “Urinary tract infection in severely malnourished children at the University of Maiduguri Teaching Hospital,” Journal of Tropical Pediatrics, vol. 48, no. 6, pp. 359–361, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. R. P. Reed and F. O. Wegerhoff, “Urinary tract infection in malnourished rural African children,” Annals of Tropical Paediatrics, vol. 15, no. 1, pp. 21–26, 1995. View at Google Scholar · View at Scopus
  36. U. K. Kala and D. W. C. Jacobs, “Evaluation of urinary tract infection in malnourished black children,” Annals of Tropical Paediatrics, vol. 12, no. 1, pp. 75–81, 1992. View at Google Scholar · View at Scopus
  37. N. Lloyd-Evans, B. S. Drasar, and A. M. Tomkins, “A comparison of the prevalence of Campylobacter, Shigellae and Salmonellae in faeces of malnourished and well nourished children in The Gambia and Northern Nigeria,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 77, no. 2, pp. 245–247, 1983. View at Google Scholar · View at Scopus
  38. A. G. Falade, H. Tschappeler, B. M. Greenwood, and E. K. Mulholland, “Use of simple clinical signs to predict pneumonia in young Gambian children: the influence of malnutrition,” Bulletin of the World Health Organization, vol. 73, no. 3, pp. 299–304, 1995. View at Google Scholar · View at Scopus
  39. A. G. Falade, E. K. Mulholland, R. A. Adegbola, and B. M. Greenwood, “Bacterial isolates from blood and lung aspirate cultures in Gambian children with lobar pneumonia,” Annals of Tropical Paediatrics, vol. 17, no. 4, pp. 315–319, 1997. View at Google Scholar · View at Scopus
  40. B. Blomberg, K. P. Manji, W. K. Urassa et al., “Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study,” BMC Infectious Diseases, vol. 7, article 46, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. C. M. Kunin, “Resistance to antimicrobial drugs—a worldwide calamity,” Annals of Internal Medicine, vol. 118, no. 7, pp. 557–561, 1993. View at Google Scholar · View at Scopus