Table 3: Literature notes about studies dealing with lag time from first symptoms to diagnosis in childhood leukemia.

StudyDiagnostic delay, median (IQR), daysPopulation diagnosed after 30 days, %Characteristic of population
Patient delayPhysician delayLag time

HIC (countries with GNP per capita income of $12.196 or more according to the World Bank Classification)Klein Geltink et al. [10] Canada7 (1–19)1 (0–11)NA*NA*826 patients aged 0–15 (1995–2000)
Thulesius et al. [12] Sweden7 (0–91)0 (0–63)21 (0–105)24%25 patients aged 0–16 (1984–1995)
Saha et al. [11] United KingdomNA*NA*21 (7–224)NA*65 patients aged 0–15 (1982–1990)
Flores et al. [9] U.S.A.NA*NA*NA*18,7%123 patients aged 0-20 (1976–1984)
Dang-Tan et al. [6] Canada8 (1–21)3 (1–14)19 (9–36)NA*944 patients aged 0–19 (1995–2000)
De Angelis et al. (this paper) Italy5 (1–13)7 (2–4)16.5 (7–33,5)18,5%81 patients aged 0–16 (2006–2009)

LICFajardo-Gutiérrez et al. [8] MexicoNA*NA*NA*47%1676 patients aged 0–14 (1981–1992)
B. O. James et al. [14] NigeriaNA*NA*56 (14–252)NA*9 patients aged 1–14 (2006–2008)
Stefan et al. [15] South Africa4 (NA*)22 (NA*)31 (NA*)NA*63 patients aged 0–15 (2000–2009)
De Angelis et al. (this paper) Nicaragua7 (1,5–15)16.5 (7–33,5)29 (18–44)45,7%81 patients aged 0–16 (2006–2009)

*NA: not available.