International Journal of Pediatrics / 2012 / Article / Tab 3

Review Article

Postnatal Corticosteroids for Prevention and Treatment of Chronic Lung Disease in the Preterm Newborn

Table 3

RCTs of early hydrocortisone to prevent BPD.

Study, no. of centersnPopulation: mechanically ventilated infantsTimingHydrocortisone dosing regimenRate of survival without BPD HC versus placebo, %

Watterberg et al. [49], 2 centers40BW: 500–999 g<48 h postnatal age0.5 mg/kg every 12 h for 9 days
0.25 mg/kg every 12 h for 3 days
60 versus 35 ( )
Watterberg et al. [50], 9 centers360BW: 500–999 g<48 h postnatal age0.5 mg/kg every 12 h for 12 days
0.25 mg/kg every 12 h for 3 days
35 versus 34 (OR: 1.20 (95% CI: 0.72–1.99))
Peltoniemi et al. [51], 3 centers51BW: 501–1250 g <36 h postnatal age2.0 mg/kg/day tapered to0.75 mg/kg/day over 10 days64 versus 46 (OR: 1.48 (95% CI: 0.49–4.48))
Bonsante et al. [52], 2 centers50BW: 500–1249 g<48 h postnatal age0.5 mg/kg every 12 h for 9 days;
0.25 mg/kg every 12 h for 3 days
64 versus 32 ( )

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