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International Journal of Pediatrics
Volume 2012 (2012), Article ID 898924, 16 pages
http://dx.doi.org/10.1155/2012/898924
Review Article

Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions: What Is the Current State of Evidence?

1Shriners Hospital for Children–Canada, Montreal, QC, Canada H3G 1A6
2Division of Orthopaedic Surgery, McGill University, Montreal, QC, Canada H3G 1Y6

Received 3 November 2011; Accepted 29 January 2012

Academic Editor: Namik Yaşar Özbek

Copyright © 2012 Noémi Dahan-Oliel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. National Center for Health Statistics, National Ambulatory Medical Care Survey, 2003.
  2. National Center for Health Statistics , National Hospital Discharge Survey, 2003.
  3. B. J. Hoare, M. A. Wallen, C. Imms, E. Villanueva, H. B. Rawicki, and L. Carey, “Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy (UPDATE),” Cochrane Database of Systematic Reviews, no. 3, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. B. Lukban, R. L. Rosales, and D. Dressler, “Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence,” Journal of Neural Transmission, vol. 116, no. 3, pp. 319–331, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. L. A. Koman, B. P. Smith, and R. Balkrishnan, “Spasticity associated with cerebral palsy in children: guidelines for the use of botulinum A toxin,” Pediatric Drugs, vol. 5, no. 1, pp. 11–23, 2003. View at Google Scholar · View at Scopus
  6. M. Brin and K. Aoki, “Botulinum toxin type A: pharmacology,” in Spasticity, Etiology, Evaluation, Management and the Role of Botulinum Toxin, N. Mayer and D. Simpson, Eds., p. 111, We Move Worldwide Education, New York, NY, USA, 2002. View at Google Scholar
  7. M. Brin and K. Aoki, “Botulinum toxin type A: pharmacology,” in Spasticity, Etiology, Evaluation, Management and the Role of Botulinum Toxin, N. Mayer and D. Simpson, Eds., pp. 110–124, We Move Worldwide Education, New York, NY, USA, 2005. View at Google Scholar
  8. J. Tsui, A. Eisen, E. Mak, M. Carruthers, A. Scott, and D. Calne, “A pilot study on the use of botuinum toxin in spasmodic torticolis,” Canadian Journal Neurological Sciences, vol. 12, pp. 314–316, 1985. View at Google Scholar
  9. H. Schaible, G. Segond von Banchet, A. Ebersberger, and G. Natura, “Involvement of CGRP in nociceptive processing and hyperalgesia: effects on spinal and dorsal root ganglion neurons,” in Hyperalgesia: Molecular Mechanisms and Clinical Implications, K. Brune and H. Handwerker, Eds., Progress in Pain Research and Management, pp. 201–228, Seattle, Wash, USA, 2004. View at Google Scholar
  10. G. E. Francisco, “Botulinum toxin: dosing and dilution,” American Journal of Physical Medicine and Rehabilitation, vol. 83, supplement 10, pp. S30–S37, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. O. Bakheit, “Botulinum toxin in the management of childhood muscle spasticity: comparison of clinical practice of 17 treatment centres,” European Journal of Neurology, vol. 10, no. 4, pp. 415–419, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Ramachandran and D. M. Eastwood, “Botulinum toxin and its orthopaedic applications,” Journal of Bone and Joint Surgery, vol. 88, no. 8, pp. 981–987, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Alberto, “Terminology for preparations of botulinum neurotoxins: what a difference a name makes,” Journal of the American Medical Association, vol. 305, no. 1, pp. 89–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. T. M. Seyler, B. P. Smith, D. R. Marker et al., “Botulinum neurotoxin as a therapeutic modality in orthopaedic surgery: more than twenty years of experience,” Journal of Bone and Joint Surgery, vol. 90, no. 4, pp. 133–145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Lowe, I. Novak, and A. Cusick, “Repeat injection of botulinum toxin A is safe and effective for upper limb movement and function in children with cerebral palsy,” Developmental Medicine and Child Neurology, vol. 49, no. 11, pp. 823–829, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Molenaers, A. van Campenhout, K. Fagard, J. de Cat, and K. Desloovere, “The use of botulinum toxin A in children with cerebral palsy, with a focus on the lower limb,” Journal of Children's Orthopaedics, vol. 4, no. 3, pp. 183–195, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. R. Delgado, D. Hirtz, M. Aisen et al., “Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society,” Neurology, vol. 74, no. 4, pp. 336–343, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Aoki and K. Martin, “Pharmacology in pain relief,” in Botulinum Toxin Type A In Pain Management. A Clinician's Guide, M. K. Childers, Ed., pp. 31–40, Academic Information Systems, 2nd edition, 2002. View at Google Scholar
  19. S. J. O'flaherty, V. Janakan, A. M. Morrow, A. M. Scheinberg, and M. A. Waugh, “Adverse events and health status following botulinum toxin type A injections in children with cerebral palsy,” Developmental Medicine and Child Neurology, vol. 53, no. 2, pp. 125–130, 2011. View at Publisher · View at Google Scholar
  20. N. H. Robin, “Congenital muscular torticollis,” Pediatrics in Review, vol. 17, no. 10, pp. 374–375, 1996. View at Google Scholar · View at Scopus
  21. S. S. Freed and C. Coulter-O'Berry, “Identification and treatment of congenital muscular torticollis in infants,” Journal of Prosthetics and Orthotics, vol. 16, supplement 4, pp. S18–S23, 2004. View at Google Scholar · View at Scopus
  22. B. L. Luther, “Congenital muscular torticollis,” Orthopaedic Nursing, vol. 21, no. 3, pp. 21–27, 2002. View at Google Scholar · View at Scopus
  23. V. Dubowitz, “The muscular dystrophies,” in Muscle Disorders in Childhood, pp. 34–133, WB Saunders, London, UK, 1995. View at Google Scholar
  24. S. J. Laaveg and I. V. Ponseti, “Long-term results of treatment of congenital clubfoot,” Journal of Bone & Joint Surgery, vol. 62, pp. 23–31, 1980. View at Google Scholar
  25. I. V. Ponseti, Congenital Clubfoot: Fundamentals of Treatment, Oxford University Press, New York, NY, USA, 1996.
  26. R. Engelbert, J. W. Gorter, C. Uiterwaal, E. Van De Putte, and P. Helders, “Idiopathic toe-walking in children, adolescents and young adults: a matter of local or generalised stiffness?” BMC Musculoskeletal Disorders, vol. 12, article 61, 2011. View at Publisher · View at Google Scholar
  27. M. Nelitz, S. Lippacher, R. Krauspe, and H. Reichel, “Perthes disease: current principles of diagnosis and treatment,” Deutsches Arzteblatt, vol. 106, no. 31-32, pp. 517–523, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. G. De Bastiani, R. Aldegheri, L. Renzi-Brivio, and G. Trivella, “Limb lengthening by callus distraction (callotasis),” Journal of Pediatric Orthopaedics, vol. 7, no. 2, pp. 129–134, 1987. View at Google Scholar · View at Scopus
  29. N. Maffulli, C. Lombari, L. Matarazzo, U. Nele, G. Pagnotta, and J. A. Fixsen, “A review of 240 patients undergoing distraction osteogenesis for congenital post-traumatic or postinfective lower limb length discrepancy,” Journal of the American College of Surgeons, vol. 182, no. 5, pp. 394–402, 1996. View at Google Scholar · View at Scopus
  30. D. I. Zafeiriou and K. Psychogiou, “Obstetrical brachial plexus palsy,” Pediatric Neurology, vol. 38, no. 4, pp. 235–242, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Bahm, M. Becker, C. Disselhorst–Klug, S. Williams, L. Meinecke, H. Müller et al., “Surgical strategy in obstetric brachial plexus palsy: the aachen experience,” Seminars in Plastic Surgery, vol. 18, pp. 285–299, 2004. View at Google Scholar
  32. M. Bouchard, S. Chouinard, and A. O. Suchowersky, “Adult cases of congenital muscular torticollis successfully treated with botulinum toxin,” Movement Disorders, vol. 25, no. 14, pp. 2453–2456, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Collins and J. Jankovic, “Botulinum toxin injection for congenital muscular torticollis presenting in children and adults,” Neurology, vol. 67, no. 6, pp. 1083–1085, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. B. Joyce and T. M. B. de Chalain, “Treatment of recalcitrant idiopathic muscular torticollis in infants with botulinum toxin type A,” Journal of Craniofacial Surgery, vol. 16, no. 2, pp. 321–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. J. L. Oleszek, N. Chang, S. D. Apkon, and P. E. Wilson, “Botulinum toxin type A in the treatment of children with congenital muscular torticollis,” American Journal of Physical Medicine and Rehabilitation, vol. 84, no. 10, pp. 813–816, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. L. O. Von Wendt and I. S. Autti-Rämö, “Botulinum toxin for amelioration of knee contracture in Duchenne muscular dystrophy,” European Journal of Paediatric Neurology, vol. 3, no. 4, pp. 175–176, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. C. M. Alvarez, M. A. De Vera, H. Chhina, L. Williams, K. Durlacher, and S. Kaga, “The use of botulinum type A toxin in the treatment of idiopathic clubfoot: 5-Year follow-up,” Journal of Pediatric Orthopaedics, vol. 29, no. 6, pp. 570–575, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. C. M. Alvarez, S. J. Tredwell, S. P. Keenan et al., “Treatment of idiopathic clubfoot utilizing botulinum A toxin: a new method and its short-term outcomes,” Journal of Pediatric Orthopaedics, vol. 25, no. 2, pp. 229–235, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. R. J. Cummings, “The effectiveness of botulinum A toxin as an adjunct to the treatment of clubfeet by the Ponseti method: a randomized, double blind, placebo controlled study,” Journal of Pediatric Orthopaedics, vol. 29, no. 6, pp. 564–569, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. P. D. Mitchell, M. Tisdall, and H. G. Zadeh, “Selective botulinum toxin injection in the treatment of recurrent deformity following surgical correction of club foot: a preliminary report of 3 children,” Acta Orthopaedica Scandinavica, vol. 75, no. 5, pp. 630–633, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. M. R. Delgado, H. Wilson, C. Johnston, S. Richards, and L. Karol, “A preliminary report of the use of botulinum toxin type A in infants with clubfoot: four case studies,” Journal of Pediatric Orthopaedics, vol. 20, no. 4, pp. 533–538, 2000. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Engström, E. M. Gutierrez-Farewik, Å. Bartonek, K. Tedroff, C. Orefelt, and Y. Haglund-Åkerlind, “Does botulinum toxin A improve the walking pattern in children with idiopathic toe-walking?” Journal of Children's Orthopaedics, vol. 4, no. 4, pp. 301–308, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. D. Brunt, R. Woo, H. D. Kim, M. S. Ko, C. Senesac, and S. Li, “Effect of botulinum toxin type A on gait of children who are idiopathic toe-walkers,” Journal of Surgical Orthopaedic Advances, vol. 13, no. 3, pp. 149–155, 2004. View at Google Scholar · View at Scopus
  44. L. K. Jacks, D. M. Michels, B. P. Smith, L. A. Koman, and J. Shilt, “Clinical usefulness of botulinum toxin in the lower extremity,” Foot and Ankle Clinics, vol. 9, no. 2, pp. 339–348, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. R. C. Hamdy, K. Montpetit, E. M. Raney et al., “Botulinum toxin type a injection in alleviating postoperative pain and improving quality of life in lower extremity limb lengthening and deformity correction: a pilot study,” Journal of Pediatric Orthopaedics, vol. 29, no. 5, pp. 427–434, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Ezaki, K. Malungpaishrope, R. J. Harrison et al., “OnabotulinumtoxinA injection as an adjunct in the treatment of posterior shoulder subluxation in neonatal brachial plexus palsy,” Journal of Bone and Joint Surgery, vol. 92, no. 12, pp. 2171–2177, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. A. E. Price, P. DiTaranto, I. Yaylali, M. A. Tidwell, and J. A. I. Grossman, “Botulinum toxin type A as an adjunct to the surgical treatment of the medial rotation deformity of the shoulder in birth injuries of the brachial plexus,” Journal of Bone and Joint Surgery, vol. 89, no. 3, pp. 327–329, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Basciani and D. Intiso, “Botulinum toxin type-A and plaster cast treatment in children with upper brachial plexus palsy,” Pediatric Rehabilitation, vol. 9, no. 2, pp. 165–170, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. C. DeMatteo, J. R. Bain, V. Galea, and D. Gjertsen, “Botulinum toxin as an adjunct to motor learning therapy and surgery for obstetrical brachial plexus injury,” Developmental Medicine and Child Neurology, vol. 48, no. 4, pp. 245–252, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. C. O. Heise, L. R. Gonçalves, E. R. Barbosa, and J. L. D. Gherpelli, “Botulinum toxin for treatment of cocontractions related to obstetrical brachial plexopathy,” Arquivos de Neuro-Psiquiatria, vol. 63, no. 3 A, pp. 588–591, 2005. View at Google Scholar · View at Scopus
  51. J. A. I. Grossman, P. DiTaranto, I. Yaylali, I. Alfonso, L. E. Ramos, and A. E. Price, “Shoulder function following late neurolysis and bypass grafting for upper brachial plexus birth injuries,” Journal of Hand Surgery, vol. 29, no. 4, pp. 356–358, 2004. View at Publisher · View at Google Scholar · View at Scopus
  52. J. A. I. Grossman, A. E. Price, M. A. Tidwell, L. E. Ramos, I. Alfonso, and I. Yaylali, “Outcome after later combined brachial plexus and shoulder surgery after birth trauma,” Journal of Bone and Joint Surgery, vol. 85, no. 8, pp. 1166–1168, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. R. Hierner, J. D. Rollnik, A. C. Berger, and R. Dengler, “Botulinum toxin type a for the treatment of biceps/triceps co-contraction in obstetrical brachial plexus lesions. Preliminary results after a follow-up of 18 months,” European Journal of Plastic Surgery, vol. 24, no. 1, pp. 2–6, 2001. View at Publisher · View at Google Scholar · View at Scopus
  54. M. T. Desiato and B. Risina, “The role of botulinum toxin in the neuro-rehabilitation of young patients with brachial plexus birth palsy,” Pediatric Rehabilitation, vol. 4, no. 1, pp. 29–36, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. J. D. Rollnik, R. Hierner, M. Schubert et al., “Botulinum toxin treatment of cocontractions after birth-related brachial plexus lesions,” Neurology, vol. 55, no. 1, pp. 112–114, 2000. View at Google Scholar · View at Scopus
  56. D. Gobets, H. Beckerman, V. D. Groot, M. H. Van Doorn-Loogman, and J. G. Becher, “Indications and effects of botulinum toxin A for obstetric brachial plexus injury: a systematic literature review,” Developmental Medicine and Child Neurology, vol. 52, no. 6, pp. 517–528, 2010. View at Publisher · View at Google Scholar · View at Scopus