Associated Factors of Acute Chest Syndrome in Children with Sickle Cell Disease in French Guiana
Table 1
Case and control description and bivariate and multivariate analysis*.
Variables
Cases (%)
Controls (%)
Bivariate analysis
Multivariate analysis
Crude OR (95% CI)
Adjusted OR (95% CI)
Age (years)
0–4
2 (8)
25 (33)
1
5–9
14 (59)
21 (27)
0.12 (0.02, 0.59)
0.009
10–14
6 (25)
15 (20)
0.2 (0.04, 1.12)
0.07
15–19
2 (8)
15 (20)
0.6 (0.08, 4.72)
0.63
Sex
M
13 (54)
43 (57)
1
F
11 (46)
33 (43)
1.1 (0.44, 2.77)
0.84
Type of haemoglobin
SS
20 (83)
45 (59)
1
S thal or SC
4 (17)
31 (41)
0.29 (0.09, 0.93)
0.038
History of treatment by hydroxyurea
Yes
4 (17)
11 (14)
1
No
20 (83)
65 (86)
0.85 (0.24, 2.95)
0.79
Duration of hospitalization (days)
>7
14 (58)
12 (16)
4.23 (2.64, 6.3)
<0.01
3.69 (2.30–5.56)
<0.01
0–7
10 (42)
64 (84)
1
Age during the first symptoms
1 year
5 (21)
34 (45)
1
Before 1 year
19 (79)
42 (55)
3.08 (1.04, 9.09)
0.04
History of >3 annual hospitalisations
Yes
19 (79)
26 (34)
7.31 (2.45, 21.8)
<0.01
5.44 (3.59–8.21)
0.003
No
5 (21)
50 (66)
1
Basic haemoglobin level
>8 g/dL
3 (12)
31 (41)
1
0–8 g/dL
21 (88)
45 (59)
4.82 (1.32, 17.58)
0.15
4.96 ( 1.29–27.34)
0.04
Basic S haemoglobin level
≥80%
20 (83)
39 (51)
1
<80%
4 (17)
37 (49)
0.21 (0.07, 0.68)
0.009
Transthoracic echocardiography
Normal
15 (63)
70 (95)
1
Abnormal
9 (37)
4 (5)
10.5 (2.85, 38.65)
<0.001
13.77 (2.07–91.46)
0.003
Transcranial echo-Doppler
Normal
19 (79)
72 (97)
1
Abnormal
5 (21)
2 (3)
9.47 (1.7, 52.69)
0.01
Obtained using conditional logistic regression with indicator variables for nonbinary variables. Bold fonts: OR (95% CI) of multivariate analysis. Italic fonts: P-value of multivariate analysis.
