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International Journal of Pediatrics
Volume 2014, Article ID 918907, 4 pages
http://dx.doi.org/10.1155/2014/918907
Research Article

Neonatal Meningitis by Multidrug Resistant Elizabethkingia meningosepticum Identified by 16S Ribosomal RNA Gene Sequencing

1Department of Microbiology, Niloufer Hospital for Women and Children, Hyderabad 500004, India
2GHR Micro Diagnostics, Hyderabad 500082, India
3Department of Pediatrics, Niloufer Hospital for Women and Children, Hyderabad 500004, India

Received 11 November 2013; Accepted 18 December 2013; Published 9 February 2014

Academic Editor: Lavjay Butani

Copyright © 2014 V. V. Shailaja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Clinical and microbiological profile of 9 neonates with meningitis by Elizabethkingia meningosepticum identified by 16S ribosomal gene sequencing was studied. All the clinical isolates were resistant to cephalosporins, aminoglycosides, trimethoprim-sulfamethoxazole, β-lactam combinations, carbapenems and only one isolate was susceptible to ciprofloxacin. All the isolates were susceptible to vancomycin. Six of nine neonates died even after using vancomycin, based on susceptibility results. E. meningosepticum meningitis in neonates results in high mortality rate. Though the organism is susceptible to vancomycin in vitro, its efficacy in vivo is questionable and it is difficult to determine the most appropriate antibiotic for treating E. meningosepticum meningitis in neonates.