A previous study conducted at the same institution, with a patient population of 77, concluded that high dose dexmedetomidine can be successfully used for MRI sedation in children, with 29% of patients requiring additional agents for optimal sedation . In our study, over the course of five years, the patient cohort was larger (544 patients) and included the previously reported 77-patient cohort. This larger patient cohort analysis validated previously reported data: 100% success of the existing sedation protocol, rounded up from 99.8% acknowledging one patient failure, with the adjunctive sedative agents used on 21.5% of cases.