Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit

Table 3

Frequency and odds ratios of neonatal outcomes in group exposed to ranitidine/omeprazole.

Outcome	Not exposed to ranitidine/omeprazole ()	Exposed to ranitidine/omeprazole ()	Odds ratio (95% CI)	value
Total late onset sepsis (culture positive + clinical sepsis)	33.1% (98)	26.6% (17)	0.73 (0.4–1.34)	0.384
Culture positive late onset sepsis	24% (71)	14.1% (9)	0.52 (0.24–1.1)	0.117
NEC (all stages)	8.4% (25)	3.1% (2)	0.35 (0.08–1.5)	0.192
NEC Bell stage ≥2	3.7% (11)	1.6% (1)	0.4 (0.05–3.2)	0.7
Mortality	8.4% (25)	3.1% (2)	0.35 (0.08–1.5)	0.19
	0.7% (2)	3.1% (2)	4.7 (0.65–34.3)	0.147
	1.7% (5)	3.1% (2)	1.9 (0.36–9.9)	0.613

Values may be underestimates due to underreporting and poor documentation in NICU.