International Journal of Pediatrics / 2018 / Article / Tab 2

Research Article

A Pooled Analysis of Growth and Tolerance of Infants Exclusively Fed Partially Hydrolyzed Whey or Intact Protein-Based Infant Formulas

Table 2

Adjusted percentages (95% CIs) of stool consistency at 1, 2, 3, and 4 months, by formula group based on a pooled analysis of individual data from four Nestlé PHF-W (Good Start) growth studies and 3 Nestlé CMF (Nan) growth studies.

AgeConsistency CategoryActual Pooled Percentage of Stool Consistency ()Adjusted Percentage of Stool Consistency and 95% CI ()p-value
CMFPHF-WCMFPHF-W

1 monthLiquid4%7%4.1% (2.2, 6.1)6.6% (4.5, 8.8)0.073
Soft49%79%48.9% (45.6, 52.2)81.1% (78.6, 83.5)<0.001
Formed31%11%36.7% (33.6, 39.9)11.1% (9.5, 12.6)<0.001
Hard11%1%10.2% (8.1, 12.3)1.2% (0.6, 1.7)<0.001

2 monthsLiquid4%5%4.5% (2.6, 6.4)7.8% (5.5, 10.0)0.022
Soft44%80%52.0% (49.6, 54.4)80.2% (77.9, 82.4)<0.001
Formed42%11%37.4% (35.2, 39.6)11.2% (10.2, 12.3)<0.001
Hard4%1%6.1% (5.1, 7.2)0.8% (0.5, 1.1)<0.001

3 monthsLiquid5%8%4.8% (6.5, 11.6)9.1% (6.5, 11.6)0.007
Soft48%78%54.2% (51.6, 56.8)79.0% (76.5, 81.5)<0.001
Formed36%11%37.4% (34.9, 39.8)11.4% (10.2, 12.6)<0.001
Hard3%1%3.6% (2.6, 4.6)0.5% (0.2, 0.8)<0.001

4 monthsLiquid4%10%5.1% (2.7, 7.5)10.5% (7.5, 13.6)0.005
Soft56%76%55.9% (52.0, 59.7)77.6% (74.4, 80.8)<0.001
Formed31%12%36.9% (33.3, 40.6)11.5% (9.6, 13.3)<0.001
Hard3%<1%2.1% (1.2, 3.0)0.4% (0.1, 0.7)<0.001

Adjusted percentages are rescaled marginal probabilities of stool consistency obtained from a longitudinal multinomial regression model with adjustment for treatment, age and treatment-by-age interaction, and accounting for clustering within study and infant. P-values are based on comparisons of the marginal probability of stool consistency at each time point. Based on the number of multiple comparisons made, a p-value of <0.003 is considered statistically significant. Actual (unadjusted) pooled percentages are also presented here; some stools were reported but missing consistency categorization.

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