No Evidence of Abnormal Expression of Beta-Catenin and Bcl-2 Proteins in Pilomatricoma as One Clinical Feature of Tetrasomy 9p Syndrome

Figure 2

G-banding karyotype, FISH, and SNP microarray findings in the study patient. (a) Partial G-banding karyotype of chromosome 9 showing two normal chromosomes 9 and an isodicentric chromosome 9p (left) and ideogram of chromosome 9 (right). (b) SNP microarray analysis results showing an allele frequency graph (upper panel) and a log ratio graph (lower panel). Note that altered B allele frequency consistent with 4 copies of the short arm of chromosome 9, relative to 2 copies of the long arm of chromosome 9, and elevated log ratio graph for the short arm of chromosome 9. (c) FISH showing two normal chromosomes 9 (arrow) with a green signal of subtelomeric probe specific to the short arm and a red signal on the long arm of each chromosome 9. The isodicentric chromosome 9p (arrowhead) with two green signals of subtelomeric probe specific to the short arm of chromosome 9 on both ends of the chromosome.

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