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International Journal of Peptides
Volume 2010 (2010), Article ID 158102, 8 pages
Review Article

Ghrelin in Female and Male Reproduction

Unité de Physiologie de la Reproduction et des Comportements, INRA, UMR85, 37 380 Nouzilly, France

Received 5 October 2009; Revised 23 December 2009; Accepted 9 January 2010

Academic Editor: Alessandro Laviano

Copyright © 2010 Joëlle Dupont et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ghrelin and one of its functional receptors, GHS-R1a (Growth Hormone Secretagogue Receptor 1a), were firstly studied about 15 years. Ghrelin is a multifunctional peptide hormone that affects several biological functions including food intake, glucose release, cell proliferation… Ghrelin and GHS-R1a are expressed in key cells of both male and female reproductive organs in several species including fishes, birds, and mammals suggesting a well-conserved signal through the evolution and a role in the control of fertility. Ghrelin could be a component of the complex series of nutrient sensors such as adipokines, and nuclear receptors, which regulate reproduction in function of the energy stores. The objective of this paper was to report the available information about the ghrelin system and its role at the level of the hypothalamic-pituitary-gonadal axis in both sexes.