TY - JOUR A2 - Inui, Akio AU - Sangiao-Alvarellos, Susana AU - Cordido, Fernando PY - 2010 DA - 2010/02/09 TI - Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications SP - 234709 VL - 2010 AB - Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin were focused on its orexigenic ability, but despite indisputable pharmacological data, the evidence for a physiological role for ghrelin in the control of appetite is much less clear. Mice with targeted deletion of either ghrelin or the GHSR exhibit an essentially normal metabolic phenotype when fed a regular chow diet, suggesting that ghrelin may have a redundant role in the regulation of food intake. RNAs for ghrelin as well as GHSR are expressed in the pancreas of rats and humans and several studies propose that ghrelin could have an important function in glucose homeostasis and insulin release, independent of GH secretion. Low plasma ghrelin levels are associated with elevated fasting insulin levels and insulin resistance, suggesting both physiological and pathophysiological roles for ghrelin. For this reason, at least theoretically, ghrelin and/or its signalling manipulation could be useful for the treatment or prevention of diseases of glucose homeostasis such as type 2 diabetes. SN - 1687-9767 UR - https://doi.org/10.1155/2010/234709 DO - 10.1155/2010/234709 JF - International Journal of Peptides PB - Hindawi Publishing Corporation KW - ER -