Ghrelin: Central Nervous System Sites of Action in Regulation of Energy Balance

Figure 2

Ghrelin modulates the electrical activity of AP neurons. (a) Nissl-stained coronal section showing the AP, along with surrounding areas including NTS. ((b) and (c)) Representative current-clamp recordings from dissociated AP neurons that were depolarized or hyperpolarized by focally applied 10 nM ghrelin. The electrophysiological effects were caused by activation of a cation conductance (depolarization) or activation of K⁺ current (hyperpolarization); see [44].

(a)

(b)

(c)