Comparison of amino acid sequence for chicken (GenBank accession no. NP_001001131) and human (GenBank accession no. NP_001128413) perproghrelin precursor proteins and the major peptides processed from the precursor including a signal peptide, the mature ghrelin peptide, C-terminal peptide, and obestatin (shown in gray box). *indicates amino acid identity. The C-terminal glycine (G) residue used to amidate the human obestatin peptide is indicated. Basic amino acids delineating proteolytic cleavage sites are shown in bold italic typeface. The Ser3 acylation site within the “active core” of the mature ghrelin peptide is indicated. The location of a single nucleotide polymorphism (SNP) resulting in an amino acid change (glutamine/arginine) located in the C-terminal peptide of the chicken precursor is shown.
