Interactions of Gastrointestinal Peptides: Ghrelin and Its Anorexigenic Antagonists

Table 2

Interference between ghrelin and leptin.

Reference	Interaction
Barazzoni 2003 [144]	Leptin injection reduces starvation-induced ghrelin secretion.
Toshinai 2001 [138]	Leptin administration increases ghrelin mRNA level in the stomach
Dixit 2004 [145]	Ghrelin inhibits leptin-induced cytokine expression
Nakazato 2001, Kim 2004 [21, 146]	Ghrelin reverses leptin-induced feeding reduction
Shintani 2001, Kohno 2003, Kohno 2007 [37, 39, 147]	Leptin suppresses Ghrelin-induced activation of NPY neurons within the ARC
Rosicka 2003, Park 2005 [148, 149]	Ghrelin and leptin levels are reversely correlated and depend on the BMI
Bagnasco 2002, Beretta 2002, Dube 2002, Bagnasco 2003 [150–153]	Central transgenic leptin expression elevates serum ghrelin levels