Figure 5: Different mechanisms of processing and cleavage of ADP-ribosylated proteins. The complete removal of the ADP-ribose, catalyzed by an ADP-ribosylarginine hydrolase is indicated in red. The picture in blue frame shows the phosphodiesterase-catalyzed cleavage of the ADP-ribosylated-protein, giving a phosphoribosylated protein. The picture in the green frame represents the nonenzymatic processing of the ADP-ribosylated protein to the ornithinylated form as described for HNP-1.