Applications of Propargyl Esters of Amino Acids in Solution-Phase Peptide Synthesis

Table 1

Preparation and deprotection of propargyl esters.

Entry	N-protected amino acids	Propargyl esters	Yield^a (%) of the esters	Yield^a (%) after deprotection
1			98	84
2			95	80
3			96	88
4			92	86
5			92	85
6			94	85
7			95	80
8			82	74
9			90	88
10			88	88
11			92	87
12			94	83
13			97	92
14			81	79
15			94	86

^aThe yields reported are of pure compounds isolated through column chromatography.