Large Scale Solid Phase Synthesis of Peptide Drugs: Use of Commercial Anion Exchange Resin as Quenching Agent for Removal of Iodine during Disulphide Bond Formation

Table 1

Resins of different loading capacity tried during Desmopressin scale up.

Resin	Particle size (𝜇m)	Matrix	Loading (mmol/g)
Tentagel SRAM	90	Poly(oxyethylene)-RAM Polymer bound	0.24
Rink amide resin	100–200	Amino methyl polystyrene crosslinked with 1% DVB	1.1
Rink amide resin	100–200	Amino methyl polystyrene crosslinked with 1% DVB	0.43
2-chlorotrityl chloride resin	100–200	Polystyrene crosslinked with 1% DVB	0.7–0.9