Large Scale Solid Phase Synthesis of Peptide Drugs: Use of Commercial Anion Exchange Resin as Quenching Agent for Removal of Iodine during Disulphide Bond Formation

Table 2

Recovery yield of disulphide peptide quenched with anion exchange resin.

Peptide	Peptide conc (mL/g)	MeOH (%)	Crude purity (%)	Yield (%) crude	Yield (%) purified	Quenching agent
Desmopressin; (Thiol)	350	85	90	80	50	Anion; exchange resin
Desmopressin; (Acm)	300	80	85	78	48	Anion; exchange resin
Octreotide	200	95	88	85	58	Anion; exchange resin
Oxytocin	450	80	82	82	47	Anion; exchange resin
Desmopressin; (Acm)	300	80	69	70 (including ascorbic acid)	30	Ascorbic acid
Octreotide	200	95	70	72 (including ascorbic acid)	32	Ascorbic acid