Proline Rich Motifs as Drug Targets in Immune Mediated Disorders

Table 2

The proline-rich motif (PRM) and the proline-rich motif binding (PRB) domain in immune-related proteins.

	Protein receptor	PRM	PRM interactant	PRD critical residue	Evidence
Membrane associated	CD28	MYPPPY	CD80	Y71	Mutagenesis
	CD152	MYPPPY	CD86	F	Mutagenesis, structural analysis
	ICOS	FDPPP	ICOSL	Y53	Mutagenesis, molecular model
Cytoplasmic	WIP	LPPP	WASP	WHI1 domain, W54	Structural analysis
Signal transduction	GILZ	PXX	p65	TAD (F534. F542)	Immunoprecipitation
Transcriptional cofactors	p53	PXXP	p300	(SPC1 192–337) SPC-2 (1737–1913)	ChIP
	SMRT	PXLXP	p65	TAD	GST pull-down assays
	SMRT		MCTF	MYND domain	Mutagenesis
			EA1	MYND domain	Solution structure
			ETO	MYND domain	Solution structure

Myc-related cellular transcription factor; viral oncoproteins EA1; ETO (a nuclear corepressor protein) chromatin immunoprecipitation.