Table of Contents
International Journal of Peptides
Volume 2012, Article ID 745027, 6 pages
http://dx.doi.org/10.1155/2012/745027
Research Article

A Novel Cellular Model to Study Angiotensin II AT2 Receptor Function in Breast Cancer Cells

1Inserm, U1016, Institut Cochin, Paris, France
2CNRS, UMR 8104, Paris, France
3University Paris Descartes, Paris, France
4Department of Biochemistry and Immunology, Faculty of Medicine at Ribeirao Preto, University of São Paulo, 14049-900 Ribeirao Preto, SP, Brazil

Received 29 June 2011; Revised 6 September 2011; Accepted 6 September 2011

Academic Editor: Jean-Marie Zajac

Copyright © 2012 Sylvie Rodrigues-Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Paulis and T. Unger, “Novel therapeutic targets for hypertension,” Nature Reviews Cardiology, vol. 7, no. 8, pp. 431–441, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. M. Bader, “Tissue renin-angiotensin-aldosterone systems: targets for pharmacological therapy,” Annual Review of Pharmacology and Toxicology, vol. 50, pp. 439–465, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. F. Deshayes and C. Nahmias, “Angiotensin receptors: a new role in cancer?” Trends in Endocrinology and Metabolism, vol. 16, no. 7, pp. 293–299, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. C. Bouquet, N. Lamandé, M. Brand et al., “Suppression of angiogenesis, tumor growth, and metastasis by adenovirus-mediated gene transfer of human angiotensinogen,” Molecular Therapy, vol. 14, no. 2, pp. 175–182, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. F. Vincent, P. Bonnin, M. Clemessy et al., “Angiotensinogen delays angiogenesis and tumor growth of hepatocarcinoma in transgenic mice,” Cancer Research, vol. 69, no. 7, pp. 2853–2860, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. L. Chow, L. Rezmann, K. J. Catt et al., “Role of the renin-angiotensin system in prostate cancer,” Molecular and Cellular Endocrinology, vol. 302, no. 2, pp. 219–229, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. A. J. George, W. G. Thomas, and R. D. Hannan, “The renin-angiotensin system and cancer: old dog, new tricks,” Nature Reviews Cancer, vol. 10, no. 11, pp. 745–759, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. T. Dolley-Hitze, F. Jouan, B. Martin et al., “Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma,” British Journal of Cancer, vol. 103, no. 11, pp. 1698–1705, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. S. Nouet and C. Nahmias, “Signal transduction from the angiotensin II AT2 receptor,” Trends in Endocrinology and Metabolism, vol. 11, no. 1, pp. 1–6, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Mogi, M. Iwai, and M. Horiuchi, “New insights into the regulation of angiotensin receptors,” Current Opinion in Nephrology and Hypertension, vol. 18, no. 2, pp. 138–143, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. J. Stegbauer and T. M. Coffman, “New insights into angiotensin receptor actions: from blood pressure to aging,” Current Opinion in Nephrology and Hypertension, vol. 20, no. 1, pp. 84–88, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. E. Rivera, O. Arrieta, P. Guevara, A. Duarte-Rojo, and J. Sotelo, “AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma,” British Journal of Cancer, vol. 85, no. 9, pp. 1396–1399, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. M. Fujita, I. Hayashi, S. Yamashina, M. Itoman, and M. Majima, “Blockade of angiotensin AT1a receptor signaling reduces tumor growth, angiogenesis, and metastasis,” Biochemical and Biophysical Research Communications, vol. 294, no. 2, pp. 441–447, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. Miyajima, T. Kosaka, T. Asano et al., “Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis,” Cancer Research, vol. 62, no. 15, pp. 4176–4179, 2002. View at Google Scholar · View at Scopus
  15. H. Uemura, H. Ishiguro, and Y. Kubota, “Angiotensin II receptor blocker: possibility of antitumor agent for prostate cancer,” Mini-Reviews in Medicinal Chemistry, vol. 6, no. 7, pp. 835–844, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Kosugi, A. Miyajima, E. Kikuchi, T. Kosaka, Y. Horiguchi, and M. Murai, “Effect of angiotensin II type 1 receptor antagonist on tumor growth and angiogenesis in a xenograft model of human bladder cancer,” Human Cell, vol. 20, no. 1, pp. 1–9, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. K. Egami, T. Murohara, T. Shimada et al., “Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth,” Journal of Clinical Investigation, vol. 112, no. 1, pp. 67–75, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Imai, T. Hashimoto, M. Kihara et al., “Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis,” Laboratory Investigation, vol. 87, no. 2, pp. 189–198, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. D. R. Rhodes, B. Ateeq, Q. Cao et al., “AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 25, pp. 10284–10289, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. I. Sipahi, S. M. Debanne, D. Y. Rowland, D. I. Simon, and J. C. Fang, “Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials,” The Lancet Oncology, vol. 11, no. 7, pp. 627–636, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Connolly, S. Yusuf, K. Swedberg et al., “Effects of telmisartan, irbesartan, valsartan, candesartan, and losartan on cancers in 15 trials enrolling 138 769 individuals,” Journal of Hypertension, vol. 29, no. 4, pp. 623–635, 2011. View at Publisher · View at Google Scholar · View at PubMed
  22. S. Bangalore, S. Kumar, S. E. Kjeldsen et al., “Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324 168 participants from randomised trials,” The Lancet Oncology, vol. 12, no. 1, pp. 65–82, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Doi, N. Egashira, A. Kawabata et al., “Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice,” BMC Cancer, vol. 10, article 67, 2010. View at Publisher · View at Google Scholar · View at PubMed
  24. L. Pickel, T. Matsuzuka, C. Doi et al., “Overexpression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells,” Cancer Biology and Therapy, vol. 9, no. 4, pp. 277–285, 2010. View at Google Scholar · View at Scopus
  25. M. J. Brown, I. S. Mackenzie, M. J. Ashby, K. K. Balan, and D. S. Appleton, “AT2 receptor stimulation may halt progression of pheochromocytoma,” Annals of the New York Academy of Sciences, vol. 1073, pp. 436–443, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. O. Arrieta, B. Pineda-Olvera, P. Guevara-Salazar et al., “Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis,” British Journal of Cancer, vol. 99, no. 1, pp. 160–166, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. N. Clere, I. Corre, S. Faure et al., “Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis,” International Journal of Cancer, vol. 127, no. 10, pp. 2279–2291, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. B. De Paepe, V. L. Verstraeten, C. R. De Potter, and G. R. Bullock, “Increased angiotensin II type-2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression,” Histochemistry and Cell Biology, vol. 117, no. 1, pp. 13–19, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. D. E. Jenkins, Y. S. Hornig, Y. Oei, J. Dusich, and T. Purchio, “Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice,” Breast Cancer Research, vol. 7, no. 4, pp. R444–454, 2005. View at Google Scholar · View at Scopus
  30. A. Sirven, E. Ravet, P. Charneau et al., “Enhanced transgene expression in cord blood CD34+-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified TRIP lentiviral vectors,” Molecular Therapy, vol. 3, no. 4, pp. 438–448, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. A. Kieusseian, J. Chagraoui, C. Kerdudo et al., “Expression of Pitx2 in stromal cells is required for normal hematopoiesis,” Blood, vol. 107, no. 2, pp. 492–500, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. D. Lazard, M. M. Briend-Sutren, P. Villageois, M. G. Mattei, A. D. Strosberg, and C. Nahmias, “Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues,” Receptors and Channels, vol. 2, no. 4, pp. 271–280, 1994. View at Google Scholar · View at Scopus
  33. D. Lazard, P. Villageois, M. M. Briend-Sutren et al., “Characterization of a membrane glycoprotein having pharmacological and biochemical properties of an AT2 angiotensin II receptor from human myometrium,” European Journal of Biochemistry, vol. 220, no. 3, pp. 919–926, 1994. View at Google Scholar · View at Scopus
  34. X. Wu, Y. Wan, A. K. Mahalingam et al., “Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationships,” Journal of Medicinal Chemistry, vol. 49, no. 24, pp. 7160–7168, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. U. M. Steckelings, M. Larhed, A. Hallberg et al., “Non-peptide AT2-receptor agonists,” Current Opinion in Pharmacology, vol. 11, no. 2, pp. 187–192, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus