Table 1: Male rats cartilage type II collagen amino acid contents in control and with pyrazinamide administration at doses 1000 mg/kg and 2000 mg/kg of body weight (M ± m, , residues/1000 residues).

Amino acidControl (norm)Pyrazinamide 1000 mg/kgPyrazinamide 2000 mg/kg

Hydroxylysine
Lysine
Histidine
Arginine *#
Hydroxyproline
Aspartic acid
Threonine
Serine *#
Glutamic acid
Proline
Glycine
Alanine *#
Valine *#
Methionine
Isoleucine *
Leucine *
Tyrosine
Phenylalanine

M ± m: mean ± mean standard error.
* statistically significant in comparison with control.
# statistically significant pyrazinamide, 1000 mg/kg group versus pyrazinamide, 2000 mg/kg group.