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International Journal of Peptides
Volume 2013 (2013), Article ID 543028, 9 pages
Research Article

α-RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom

1CAT/CEPID, Instituto Butantan, Avenida Vital Brasil 1500, 05503-900 São Paulo, SP, Brazil
2Ministério da Ciência, Tecnologia e Inovação, Esplanada dos Ministérios, Bloco E, 70067-900 Brasília, DF , Brazil
3Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, 05508-900 São Paulo, SP, Brazil
4Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
5Laboratório de Bioquímica e Biofísica, Instituto Butantan, Avenida Vital Brasil 1500, 05503-900 São Paulo, SP, Brazil

Received 31 October 2012; Revised 16 January 2013; Accepted 16 January 2013

Academic Editor: Ayman El-Faham

Copyright © 2013 Maria Cristina Vianna Braga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The accompanying figures and tables provide information that subside the results presented in the main text. These data consist of one CLUSTALW alignment of all deposited α-conotoxins, one explanatory table with the toxin description and organism of origin and the resulting molecular phylogenetic tree built (by MEGA) on the alignment data. This tree branches provide a better visualization of the possible phylogenetic relations among the toxins. This tree served to locate the branch in which α-RgIB sits. The closest phylogenetic relatives were than reanalyzed for homology and presented in the main text. Moreover, this material also presents the expression profile of the nicotinic receptors detected in the employed cell cultures, which is important for proper pharmacological characterization.

  1. Supplementary Materials