Table of Contents
International Journal of Peptides
Volume 2015 (2015), Article ID 702784, 5 pages
http://dx.doi.org/10.1155/2015/702784
Review Article

Proteins of Bartonella bacilliformis: Candidates for Vaccine Development

1Hospital Universitario Fundacion Alcorcon, Calle Budapest 1, 28922 Madrid, Spain
2Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia, Lima 31, Peru
3Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
4ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, 08036 Barcelona, Spain

Received 31 May 2015; Revised 2 August 2015; Accepted 6 August 2015

Academic Editor: Hubert Vaudry

Copyright © 2015 Cesar Henriquez-Camacho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bartonella bacilliformis is the etiologic agent of Carrión’s disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión’s disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.