Mystixin-7 Peptide Protects Ionotropic Glutamatergic Mechanisms against Glutamate-Induced Excitotoxicity In Vitro

Figure 2

Protective effects of different concentrations MTX on the degree of preservation of activities of both AMPARs and NMDARs after exposure to glutamate in toxic concentration (20 mM). -axis: amplitudes of AMPA and NMDA EPSP (mV) after pretreatment slices by MTX and further glutamate exposure (20 mM). -axis: irregular. for every point. Note that suppression of hyperactivation of AMPARs and NMDARs induced of L-glutamate was dependent upon the concentration of MTX at pretreatment of slices with this peptide.